No. Authors Year Title Category Species
1 C. Tsangaris, V. Moschino, E. Strogyloudi, V. Coatu, A. Ramsak, R. A. Alhaija, S. Carvalho, S. Felline, A. Kosyan, Y. Lazarou, I. Hatzianestis, A. Oros and D. Tiganus 2016 Biochemical biomarker responses to pollution in selected sentinel organisms across the Eastern Mediterranean and the Black Sea Biomarker None
2 R. A. Butler and G. Roesijadi 2001 Disruption of metallothionein expression with antisense oligonucleotides abolishes protection against cadmium cytotoxicity in molluscan hemocytes Heavy metal Oysters
3 I. Boutet, A. Tanguy, M. Auffret, R. Riso and D. Moraga 2002 Immunochemical quantification of metallothioneins in marine mollusks: characterization of a metal exposure bioindicator Heavy metal Crassostrea gigas
4 A. Rodriguez-Iruretagoiena, A. Rementeria, B. Zaldibar, S. F. de Vallejuelo, A. Gredilla, G. Arana and A. de Diego 2016 Is there a direct relationship between stress biomarkers in oysters and the amount of metals in the sediments where they inhabit? Biomarker Oysters
5 R. Dallinger, B. Berger and A. Bauer-Hilty 1989 Purification of cadmium-binding proteins from related species of terrestrial Helicidae (Gastropoda, Mollusca): a comparative study Heavy metal Helix pomatia 
6 M. E. Unger and G. Roesijadi 1993 Sensitive assay for molluscan metallothionein induction based on ribonuclease protection and molecular titration of metallothionein and actin mRNAs Heavy metal Oysters
7 W. H. Hsu, Y. C. Lin, B. R. Chen, S. C. Wu and B. H. Lee 2018 The neuronal protection of a zinc-binding protein isolated from oyster Heavy metal Oysters
8 M. Xue and C. H. Ke 2012 [Cadmium bioaccumulation and its toxicity in Babylonia areolata under different nutritional status] Heavy metal Babylonia areolata
9 E. Carpene and G. Hakim 1981 [Covalent chromatography of Mytilus edulis L. thioneine using thiosepharose 4B] Heavy metal Mytilus edulis
10 G. I. Fal'fushins'ka, L. L. Gnatyshina, O. B. Stoliar, N. Mitina, O. S. Zaichenko, Z. Filiak Ie and R. S. Stoika 2011 [Evaluation of biological effects of cobalt-nanocomposites with the use of biochemical markers of bivalve mollusk Anodonta cygnea] Biomarker Anodonta cygnea
11 Z. Pokora, P. Szilman and I. Pokora 1993 [Histochemical estimation of zinc accumulation in hepato-pancreatic gland cells of the snail Lymnaea stagnalis (L.)after subacute poisoning with zinc acetate considering infection with Digenea larvae] Heavy metal Lymnaea stagnalis
12 C. D. Li, W. Yan, A. M. Long, F. J. Ma and S. Y. Chen 2007 [Metal accumulation and MTLP induction in the digestive glands of Perna viridis exposed to Cu] Heavy metal Perna viridis
13 M. Lemus, N. Rojas, L. Rojas-Astudillo and K. Chung 2013 [Metallothioneins in Perna viridis (Bivalvia: Mytilidae): seasonal variation and its relation to reproductive biology] Biomarker Perna viridis
14 H. I. Fal'fushins'ka, L. L. Hnatyshyna and O. B. Stoliar 2012 [Population-related peculiarities of molecular stress-responsive systems of bivalve mollusk under the effect of tetrazine pesticide] Toxicity Anodonta cygnea
15 O. V. Mishchuk and O. B. Stoliar 2008 [The effect of pesticide acetamiprid on biochemical markers in tissues of fresh water bivalve mussels Anodonta cygnea L. (Unionidae)] Biomarker Anodonta cygnea
16 F. Donnini, E. Dinelli, F. Sangiorgi and E. Fabbri 2007 A biological and geochemical integrated approach to assess the environmental quality of a coastal lagoon (Ravenna, Italy) Biomarker Mytilus galloprovincialis
17 M. Capolupo, S. Franzellitti, A. Kiwan, P. Valbonesi, E. Dinelli, E. Pignotti, M. Birke and E. Fabbri 2017 A comprehensive evaluation of the environmental quality of a coastal lagoon (Ravenna, Italy): Integrating chemical and physiological analyses in mussels as a biomonitoring strategy Biomarker Mytilus galloprovincialis
18 P. E. Buffet, M. Richard, F. Caupos, A. Vergnoux, H. Perrein-Ettajani, A. Luna-Acosta, F. Akcha, J. C. Amiard, C. Amiard-Triquet, M. Guibbolini, C. Risso-De Faverney, H. Thomas-Guyon, P. Reip, A. Dybowska, D. Berhanu, E. Valsami-Jones and C. Mouneyrac 2013 A mesocosm study of fate and effects of CuO nanoparticles on endobenthic species (Scrobicularia plana, Hediste diversicolor) Heavy metal Scrobicularia plana, Hediste diversicolor
19 A. Serafim, B. Lopes, R. Company, A. Cravo, T. Gomes, V. Sousa and M. J. Bebianno 2011 A multi-biomarker approach in cross-transplanted mussels Mytilus galloprovincialis Biomarker Mytilus galloprovincialis
20 A. Cravo, B. Lopes, A. Serafim, R. Company, L. Barreira, T. Gomes and M. J. Bebianno 2009 A multibiomarker approach in Mytilus galloprovincialis to assess environmental quality Biomarker Mytilus galloprovincialis
21 R. Guo, L. Pan and R. Ji 2017 A multi-biomarker approach in scallop Chlamys farreri to assess the impact of contaminants in Qingdao coastal area of China Biomarker Chlamys farreri
22 A. Cravo, C. Pereira, T. Gomes, C. Cardoso, A. Serafim, C. Almeida, T. Rocha, B. Lopes, R. Company, A. Medeiros, R. Norberto, R. Pereira, O. Araujo and M. J. Bebianno 2012 A multibiomarker approach in the clam Ruditapes decussatus to assess the impact of pollution in the Ria Formosa lagoon, South Coast of Portugal Biomarker Ruditapes decussatus
23 T. S. Galloway, R. J. Brown, M. A. Browne, A. Dissanayake, D. Lowe, M. B. Jones and M. H. Depledge 2004 A multibiomarker approach to environmental assessment Biomarker Littorina littorea, Carcinus
maenas
24 B. Lieb 2003 A new metallothionein gene from the giant keyhole limpet Megathura crenulata MT gene Megathura crenulata
25 A. R. Linde and E. Garcia-Vazquez 2006 A simple assay to quantify metallothionein helps to learn about bioindicators and environmental health Biomarker fish
26 A. Z. Mason and M. R. Borja 2002 A study of Cu turnover in proteins of the visceral complex of Littorina littorea by stable isotopic analysis using coupled HPLC-ICP-MS Heavy metal Littorina littorea
27 S. J. Han, J. S. Park and I. S. Lee 2003 Accumulation and elimination of cadmium and zinc in the Asian periwinkle Littorina brevicula Heavy metal Littorina brevicula
28 T. Gomes, C. G. Pereira, C. Cardoso, J. P. Pinheiro, I. Cancio and M. J. Bebianno 2012 Accumulation and toxicity of copper oxide nanoparticles in the digestive gland of Mytilus galloprovincialis Heavy metal Mytilus galloprovincialis
29 T. Wlostowski, P. Kozlowski, B. Laszkiewicz-Tiszczenko, E. Olenska and O. Aleksandrowicz 2014 Accumulation of cadmium in and its effect on the midgut gland of terrestrial snail Helix pomatia L. from urban areas in Poland Heavy metal Helix pomatia
30 Y. Y. Bernal-Hernandez, I. M. Medina-Diaz, M. L. Robledo-Marenco, J. B. Velazquez-Fernandez, M. I. Giron-Perez, L. Ortega-Cervantes, W. A. Maldonado-Vazquez and A. E. Rojas-Garcia 2010 Acetylcholinesterase and metallothionein in oysters (Crassostrea corteziensis) from a subtropical Mexican Pacific estuary Biomarker Crassostrea corteziensis
31 A. Sureda, X. Capo, C. Busquets-Cortes and S. Tejada 2018 Acute exposure to sunscreen containing titanium induces an adaptive response and oxidative stress in Mytillus galloprovincialis Biomarker Mytillus galloprovincialis
32 M. Erk and B. Raspor 2000 Advantages and disadvantages of voltammetric method in studying cadmium-metallothionein interactions Heavy metal Mytilus galloprovincialis
33 L. Wang, L. Song, D. Ni, H. Zhang and W. Liu 2009 Alteration of metallothionein mRNA in bay scallop Argopecten irradians under cadmium exposure and bacteria challenge Heavy metal Argopecten irradians
34 F. Gagne, C. Blaise, J. Pellerin and S. Gauthier-Clerc 2002 Alteration of the biochemical properties of female gonads and vitellins in the clam Mya arenaria at contaminated sites in the Saguenay Fjord Gene expression Mya arenaria
35 A. M. Moncaleano-Nino, S. A. Barrios-Latorre, J. F. Poloche-Hernandez, V. Becquet, V. Huet, L. Villamil, H. Thomas-Guyon, M. J. Ahrens and A. Luna-Acosta 2017 Alterations of tissue metallothionein and vitellogenin concentrations in tropical cup oysters (Saccostrea sp.) following short-term (96h) exposure to cadmium Heavy metal Saccostrea sp.
36 M. Desouky, R. Jugdaohsingh, C. R. McCrohan, K. N. White and J. J. Powell 2002 Aluminum-dependent regulation of intracellular silicon in the aquatic invertebrate Lymnaea stagnalis Detoxification Lymnaea stagnalis
37 L. Da Ros, V. Moschino, V. Macic and M. Schintu 2011 An ecotoxicological approach for the Boka Kotorska Bay (south-eastern Adriatic Sea): first evaluation of lysosomal responses and metallothionein induction in mussels Biomarker Mytilus galloprovincialis
38 S. Gorbi, C. Virno Lamberti, A. Notti, M. Benedetti, D. Fattorini, G. Moltedo and F. Regoli 2008 An ecotoxicological protocol with caged mussels, Mytilus galloprovincialis, for monitoring the impact of an offshore platform in the Adriatic Sea Biomarker Mytilus galloprovincialis
39 P. B. Lobel and J. F. Payne 1984 An evaluation of mercury-203 for assessing the induction of metallothionein-like proteins in mussels exposed to cadmium Heavy metal Mytilus edulis
40 V. P. Chelomin, M. V. Zakhartsev, A. V. Kurilenko and N. N. Belcheva 2005 An in vitro study of the effect of reactive oxygen species on subcellular distribution of deposited cadmium in digestive gland of mussel Crenomytilus grayanus Heavy metal Crenomytilus grayanus
41 L. J. Dallas, A. Turner, T. P. Bean, B. P. Lyons and A. N. Jha 2018 An integrated approach to assess the impacts of zinc pyrithione at different levels of biological organization in marine mussels Heavy metal Mytilus galloprovincialis
42 P. Goswami, G. Hariharan, N. Godhantaraman and N. Munuswamy 2014 An integrated use of multiple biomarkers to investigate the individual and combined effect of copper and cadmium on the marine green mussel (Perna viridis) Biomarker Perna viridis
43 O. Palacios, E. Jimenez-Marti, M. Niederwanger, S. Gil-Moreno, O. Zerbe, S. Atrian, R. Dallinger and M. Capdevila 2017 Analysis of Metal-Binding Features of the Wild Type and Two Domain-Truncated Mutant Variants of Littorina littorea Metallothionein Reveals Its Cd-Specific Character Heavy metal Littorina littorea
44 Q. Wang, X. Wang, X. Wang, H. Yang and B. Liu 2010 Analysis of metallotionein expression and antioxidant enzyme activities in Meretrix meretrix larvae under sublethal cadmium exposure Antioxidant Meretrix meretrix
45 X. Liu and W. X. Wang 2016 Antioxidant and detoxification responses of oysters Crassostrea hongkongensis in a multimetal-contaminated estuary Antioxidant Crassostrea hongkongensis
46 V. L. Maria and M. J. Bebianno 2011 Antioxidant and lipid peroxidation responses in Mytilus galloprovincialis exposed to mixtures of benzo(a)pyrene and copper Antioxidant Mytilus galloprovincialis
47 R. Company, A. Serafim, R. P. Cosson, A. Fiala-Medioni, L. Camus, A. Colaco, R. Serrao-Santos and M. J. Bebianno 2008 Antioxidant biochemical responses to long-term copper exposure in Bathymodiolus azoricus from Menez-Gwen hydrothermal vent Antioxidant Bathymodiolus azoricus
48 F. Geret, A. Serafim and M. J. Bebianno 2003 Antioxidant enzyme activities, metallothioneins and lipid peroxidation as biomarkers in Ruditapes decussatus? Biomarker Ruditapes decussatus
49 B. Fernandez, J. A. Campillo, C. Martinez-Gomez and J. Benedicto 2010 Antioxidant responses in gills of mussel (Mytilus galloprovincialis) as biomarkers of environmental stress along the Spanish Mediterranean coast Biomarker Mytilus galloprovincialis
50 A. Viarengo, B. Burlando, N. Ceratto and I. Panfoli 2000 Antioxidant role of metallothioneins: a comparative overview Antioxidant None
51 M. J. Bebianno, R. Company, A. Serafim, L. Camus, R. P. Cosson and A. Fiala-Medoni 2005 Antioxidant systems and lipid peroxidation in Bathymodiolus azoricus from Mid-Atlantic Ridge hydrothermal vent fields Antioxidant Bathymodiolus azoricus
52 P. Guidi, G. Frenzilli, M. Benedetti, M. Bernardeschi, A. Falleni, D. Fattorini, F. Regoli, V. Scarcelli and M. Nigro 2010 Antioxidant, genotoxic and lysosomal biomarkers in the freshwater bivalve (Unio pictorum) transplanted in a metal polluted river basin Biomarker Unio pictorum
53 S. Sforzini, C. Oliveri, A. Orru, G. Chessa, B. Pacchioni, C. Millino, A. N. Jha, A. Viarengo and M. Banni 2018 Application of a new targeted low density microarray and conventional biomarkers to evaluate the health status of marine mussels: A field study in Sardinian coast, Italy Biomarker Mytilus galloprovincialis
54 M. Giltrap, J. Ronan, C. Tanner, F. X. O'Beirn, B. P. Lyons, R. Mag Aoidh, H. Rochford, B. McHugh, E. McGovern and J. Wilson 2016 Application of a weight of evidence approach utilising biological effects, histopathology and contaminant levels to assess the health and pollution status of Irish blue mussels (Mytilus edulis) Biomarker Mytilus edulis
55 N. Chevre, F. Gagne, P. Gagnon and C. Blaise 2003 Application of rough sets analysis to identify polluted aquatic sites based on a battery of biomarkers: a comparison with classical methods Biomarker Mya arenaria
56 I. Zorita, E. Strogyloudi, A. Buxens, L. I. Mazon, E. Papathanassiou, M. Soto and M. P. Cajaraville 2005 Application of two SH-based methods for metallothionein determination in mussels and intercalibration of the spectrophotometric method: laboratory and field studies in the Mediterranean Sea Biomarker Mytilus galloprovincialis
57 E. Figueira, D. Branco, S. C. Antunes, F. Goncalves and R. Freitas 2012 Are metallothioneins equally good biomarkers of metal and oxidative stress? Biomarker Cerastoderma edule
58 M. Faria, M. A. Lopez, S. Diez and C. Barata 2010 Are native naiads more tolerant to pollution than exotic freshwater bivalve species? An hypothesis tested using physiological responses of three species transplanted to mercury contaminated sites in the Ebro River (NE, Spain) Heavy metal Dreissena polymorpha, Corbicula fluminea, Psilunio littoralis
59 F. Aouini, C. Trombini, M. Volland, M. Elcafsi and J. Blasco 2018 Assessing lead toxicity in the clam Ruditapes philippinarum: Bioaccumulation and biochemical responses Biomarker Ruditapes philippinarum
60 B. Baraj, F. Niencheski, G. Fillmann and C. De Martinez Gaspar Martins 2011 Assessing the effects of Cu, Cd, and exposure period on metallothionein production in gills of the Brazilian brown mussel Perna perna by using factorial design Heavy metal Perna perna
61 F. Dondero, A. Dagnino, H. Jonsson, F. Capri, L. Gastaldi and A. Viarengo 2006 Assessing the occurrence of a stress syndrome in mussels (Mytilus edulis) using a combined biomarker/gene expression approach Biomarker Mytilus edulis
62 V. Moschino, E. Delaney and L. Da Ros 2012 Assessing the significance of Ruditapes philippinarum as a sentinel for sediment pollution: bioaccumulation and biomarker responses Biomarker Ruditapes philippinarum
63 R. Chandurvelan, I. D. Marsden, C. N. Glover and S. Gaw 2015 Assessment of a mussel as a metal bioindicator of coastal contamination: relationships between metal bioaccumulation and multiple biomarker responses Biomarker Perna canaliculus
64 I. Zorita, I. Apraiz, M. Ortiz-Zarragoitia, A. Orbea, I. Cancio, M. Soto, I. Marigomez and M. P. Cajaraville 2007 Assessment of biological effects of environmental pollution along the NW Mediterranean Sea using mussels as sentinel organisms Biomarker Mytilus galloprovincialis
65 C. Tsangaris, E. Cotou, E. Papathanassiou and A. Nicolaidou 2010 Assessment of contaminant impacts in a semi-enclosed estuary (Amvrakikos Gulf, NW Greece): bioenergetics and biochemical biomarkers in mussels Biomarker Mussel
66 L. F. Oliveira, S. M. Silva and C. B. Martinez 2014 Assessment of domestic landfill leachate toxicity to the Asian clam Corbicula fluminea via biomarkers Biomarker Corbicula fluminea
67 M. Banni, F. Dondero, J. Jebali, H. Guerbej, H. Boussetta and A. Viarengo 2007 Assessment of heavy metal contamination using real-time PCR analysis of mussel metallothionein mt10 and mt20 expression: a validation along the Tunisian coast Heavy metal Mytilus galloprovincialis
68 Z. Dragun, M. Erk, D. Ivankovic, R. Zaja, V. Filipovic Marijic and B. Raspor 2010 Assessment of low-level metal contamination using the Mediterranean mussel gills as the indicator tissue Metal Mytilus galloprovincialis
69 Q. Liu, F. Wang, F. Meng, L. Jiang, G. Li and R. Zhou 2018 Assessment of metal contamination in estuarine surface sediments from Dongying City, China: Use of a modified ecological risk index Metal Meretrix meretrix 
70 C. Escobedo-Fregoso, L. C. Mendez-Rodriguez, P. Monsalvo-Spencer, R. A. Llera-Herrera, T. Zenteno-Savin and B. Acosta-Vargas 2010 Assessment of metallothioneins in tissues of the clam Megapitaria squalida as biomarkers for environmental cadmium pollution from areas enriched in phosphorite Biomarker Megapitaria squalida
71 M. Machreki-Ajmi and A. Hamza-Chaffai 2008 Assessment of sediment/water contamination by in vivo transplantation of the cockles Cerastoderma glaucum from a non contaminated to a contaminated area by cadmium Heavy metal Cerastoderma glaucum
72 O. Geffard, A. Geffard, E. His and H. Budzinski 2003 Assessment of the bioavailability and toxicity of sediment-associated polycyclic aromatic hydrocarbons and heavy metals applied to Crassostrea gigas embryos and larvae Heavy metal Crassostrea gigas
73 B. Fernandez, J. A. Campillo, C. Martinez-Gomez and J. Benedicto 2012 Assessment of the mechanisms of detoxification of chemical compounds and antioxidant enzymes in the digestive gland of mussels, Mytilus galloprovincialis, from Mediterranean coastal sites Antioxidant Mytilus galloprovincialis
74 P. E. Buffet, O. F. Tankoua, J. F. Pan, D. Berhanu, C. Herrenknecht, L. Poirier, C. Amiard-Triquet, J. C. Amiard, J. B. Berard, C. Risso, M. Guibbolini, M. Romeo, P. Reip, E. Valsami-Jones and C. Mouneyrac 2011 Behavioural and biochemical responses of two marine invertebrates Scrobicularia plana and Hediste diversicolor to copper oxide nanoparticles Heavy metal Scrobicularia plana, Hediste diversicolor
75 N. Nesto, S. Romano, V. Moschino, M. Mauri and L. Da Ros 2007 Bioaccumulation and biomarker responses of trace metals and micro-organic pollutants in mussels and fish from the Lagoon of Venice, Italy Biomarker Mytilus galloprovincialis, Zosterisessor ophiocephalus
76 M. Metian, M. Warnau, R. P. Cosson, F. Oberhansli and P. Bustamante 2008 Bioaccumulation and detoxification processes of Hg in the king scallop Pecten maximus: field and laboratory investigations Heavy metal Pecten maximus
77 S. Ray 1986 Bioaccumulation of cadmium in marine organisms Heavy metal Crassostrea virginica
78 A. Geffard, O. Geffard, J. C. Amiard, E. His and C. Amiard-Triquet 2007 Bioaccumulation of metals in sediment elutriates and their effects on growth, condition index, and metallothionein contents in oyster larvae Metal Crassostrea gigas
79 F. Gagne, J. Auclair, M. Fortier, A. Bruneau, M. Fournier, P. Turcotte, M. Pilote and C. Gagnon 2013 Bioavailability and immunotoxicity of silver nanoparticles to the freshwater mussel Elliptio complanata Heavy metal Elliptio complanata
80 C. P. Marasinghe Wadige, A. M. Taylor, W. A. Maher and F. Krikowa 2014 Bioavailability and toxicity of zinc from contaminated freshwater sediments: linking exposure-dose-response relationships of the freshwater bivalve Hyridella australis to zinc-spiked sediments Heavy metal Hyridella australis
81 I. Riba, M. C. Casado-Martinez, J. Blasco and T. A. DelValls 2004 Bioavailability of heavy metals bound to sediments affected by a mining spill using Solea senegalensis and Scrobicularia plana Heavy metal Solea senegalensis, Scrobicularia plana
82 F. Guo, J. Yao and W. X. Wang 2013 Bioavailability of purified subcellular metals to a marine fish Metal Terapon jarbua, Crassostrea hongkongensis
83 R. Chandurvelan, I. D. Marsden, S. Gaw and C. N. Glover 2013 Biochemical biomarker responses of green-lipped mussel, Perna canaliculus, to acute and subchronic waterborne cadmium toxicity Biomarker Perna canaliculus
84 M. J. Rodriguez-Ortega, J. Alhama, V. Funes, A. Romero-Ruiz, A. Rodriguez-Ariza and J. Lopez-Barea 2002 Biochemical biomarkers of pollution in the clam Chamaelea gallina from south-Spanish littoral Biomarker Chamaelea gallina
85 N. Kamel, J. Jebali, M. Banni, S. Ben Khedher, L. Chouba and H. Boussetta 2012 Biochemical responses and metals levels in Ruditapes decussatus after exposure to treated municipal effluents Metal Ruditapes decussatus
86 R. Wan, F. Meng, W. Fu, Q. Wang and E. Su 2015 Biochemical responses in the gills of Meretrix meretrix after exposure to treated municipal effluent Biomarker Meretrix meretrix
87 A. Sureda, A. Box, S. Tejada, A. Blanco, J. Caixach and S. Deudero 2011 Biochemical responses of Mytilus galloprovincialis as biomarkers of acute environmental pollution caused by the Don Pedro oil spill (Eivissa Island, Spain) Biomarker Mytilus galloprovincialis
88 I. Boldina-Cosqueric, J. C. Amiard, C. Amiard-Triquet, O. Dedourge-Geffard, I. Metais, C. Mouneyrac, B. Moutel and B. Berthet 2010 Biochemical, physiological and behavioural markers in the endobenthic bivalve Scrobicularia plana as tools for the assessment of estuarine sediment quality Biomarker Scrobicularia plana
89 K. Pan and W. X. Wang 2009 Biodynamics to explain the difference of copper body concentrations in five marine bivalve species Heavy metal Chlamys nobilis, Ruditapes philippinarum, Perna viridis, Septifer virgatus, Saccostrea cucullata
90 Y. Jin and W. X. Wang 2015 Biokinetics and metallothionein-like proteins response in oysters facing metal challenges in an estuary Heavy metal Crassostrea hongkongensis
91 L. H. An, B. H. Zheng, L. J. Wang, Y. Q. Zhang, H. Chen, X. R. Zhao, L. Zhang and K. Lei 2012 Biomarker responses and genotoxicity in the mud snail (Bullacta exarata) as indicators of coastal contamination Biomarker Bullacta exarata
92 D. Schiedek, K. Broeg, J. Barsiene, K. K. Lehtonen, J. Gercken, S. Pfeifer, H. Vuontisjarvi, P. J. Vuorinen, V. Dedonyte, A. Koehler, L. Balk and R. Schneider 2006 Biomarker responses as indication of contaminant effects in blue mussel (Mytilus edulis) and female eelpout (Zoarces viviparus) from the southwestern Baltic Sea Biomarker Mytilus edulis, Zoarces viviparus
93 J. Barsiene, K. K. Lehtonen, A. Koehler, K. Broeg, P. J. Vuorinen, T. Lang, J. Pempkowiak, J. Syvokiene, V. Dedonyte, A. Rybakovas, R. Repecka, H. Vuontisjarvi and J. Kopecka 2006 Biomarker responses in flounder (Platichthys flesus) and mussel (Mytilus edulis) in the Klaipeda-Butinge area (Baltic Sea) Biomarker Platichthys flesus, Mytilus edulis
94 E. Perez, J. Blasco and M. Sole 2004 Biomarker responses to pollution in two invertebrate species: Scrobicularia plana and Nereis diversicolor from the Cadiz bay (SW Spain) Biomarker Scrobicularia plana, Nereis diversicolor
95 F. Gagne, C. Blaise, I. Aoyama, R. Luo, C. Gagnon, Y. Couillard, P. Campbell and M. Salazar 2002 Biomarker study of a municipal effluent dispersion plume in two species of freshwater mussels Biomarker Elliptio complanata
96 L. Wang, L. Pan, N. Liu, D. Liu, C. Xu and J. Miao 2011 Biomarkers and bioaccumulation of clam Ruditapes philippinarum in response to combined cadmium and benzo[alpha]pyrene exposure Biomarker Ruditapes philippinarum
97 M. J. Bebianno, F. Geret, P. Hoarau, M. A. Serafim, M. R. Coelho, M. Gnassia-Barelli and M. Romeo 2004 Biomarkers in Ruditapes decussatus: a potential bioindicator species Biomarker Ruditapes decussatus
98 L. F. de Oliveira, C. Santos and C. B. Dos Reis Martinez 2016 Biomarkers in the freshwater bivalve Corbicula fluminea confined downstream a domestic landfill leachate discharge Biomarker Corbicula fluminea
99 E. Giarratano, M. N. Gil and G. Malanga 2014 Biomarkers of environmental stress in gills of ribbed mussel Aulacomya atra atra (Nuevo Gulf, Northern Patagonia) Biomarker Aulacomya atra atra
100 J. Sillero-Rios, A. Sureda, X. Capo, M. Oliver-Codorniu and P. Arechavala-Lopez 2018 Biomarkers of physiological responses of Octopus vulgaris to different coastal environments in the western Mediterranean Sea Biomarker Octopus vulgaris
101 M. L. Martin-Diaz, J. Blasco, D. Sales and T. A. Delvalls 2007 Biomarkers study for sediment quality assessment in spanish ports using the crab Carcinus maenas and the clam Ruditapes philippinarum Biomarker Ruditapes philippinarum
102 D. L. Kalpaxis, C. Theos, M. A. Xaplanteri, G. P. Dinos, A. V. Catsiki and M. Leotsinidis 2004 Biomonitoring of Gulf of Patras, N. Peloponnesus, Greece. Application of a biomarker suite including evaluation of translation efficiency in Mytilus galloprovincialis cells Biomarker Mytilus galloprovincialis
103 W. Boulajfene, E. Strogyloudi, V. A. Catsiki, A. El Mlayah and S. Tlig-Zouari 2017 Bio-monitoring of metal impact on metallothioneins levels in the gastropod Phorcus turbinatus (Born, 1778) in the northeastern and the eastern coasts of Tunisia Biomarker Phorcus turbinatus
104 M. Niederwanger, S. Calatayud, O. Zerbe, S. Atrian, R. Albalat, M. Capdevila, O. Palacios and R. Dallinger 2017 Biomphalaria glabrata Metallothionein: Lacking Metal Specificity of the Protein and Missing Gene Upregulation Suggest Metal Sequestration by Exchange Instead of through Selective Binding Heavy metal Biomphalaria glabrata
105 W. Zhang, Z. Guo, Y. Zhou, H. Liu and L. Zhang 2015 Biotransformation and detoxification of inorganic arsenic in Bombay oyster Saccostrea cucullata Heavy metal Saccostrea cucullata
106 R. P. Cosson 2000 Bivalve metallothionein as a biomarker of aquatic ecosystem pollution by trace metals: limits and perspectives Biomarker mollusc
107 X. de Montaudouin, I. Paul-Pont, C. Lambert, P. Gonzalez, N. Raymond, F. Jude, A. Legeay, M. Baudrimont, C. Dang, F. Le Grand, N. Le Goic, L. Bourasseau and C. Paillard 2010 Bivalve population health: multistress to identify hot spots Metal C. edule
108 Y. Li, H. Yang, N. Liu, J. Luo, Q. Wang and L. Wang 2015 Cadmium accumulation and metallothionein biosynthesis in cadmium-treated freshwater mussel Anodonta woodiana Heavy metal Anodonta woodiana
109 N. Geng, C. Wang, P. Wang, N. Qi and L. Ren 2015 Cadmium Accumulation and Metallothionein Response in the Freshwater Bivalve Corbicula fluminea Under Hydrodynamic Conditions Heavy metal Corbicula fluminea
110 O. Perceval, B. Pinel-Alloul, G. Methot, Y. Couillard, A. Giguere, P. G. Campbell and L. Hare 2002 Cadmium accumulation and metallothionein synthesis in freshwater bivalves (Pyganodon grandis): relative influence of the metal exposure gradient versus limnological variability Heavy metal Pyganodon grandis
111 T. Wlostowski, P. Kozlowski, B. Laszkiewicz-Tiszczenko and E. Olenska 2016 Cadmium Accumulation and Pathological Alterations in the Midgut Gland of Terrestrial Snail Helix pomatia L. from a Zinc Smelter Area: Role of Soil pH Heavy metal Helix pomatia
112 Z. S. Evtushenko, N. N. Belcheva and O. N. Lukyanova 1986 Cadmium accumulation in organs of the scallop Mizuhopecten yessoensis--II. Subcellular distribution of metals and metal-binding proteins Heavy metal Mizuhopecten yessoensis
113 Y. K. Choi, P. G. Jo and C. Y. Choi 2008 Cadmium affects the expression of heat shock protein 90 and metallothionein mRNA in the Pacific oyster, Crassostrea gigas Heavy metal Crassostrea gigas
114 V. Marie, M. Baudrimont and A. Boudou 2006 Cadmium and zinc bioaccumulation and metallothionein response in two freshwater bivalves (Corbicula fluminea and Dreissena polymorpha) transplanted along a polymetallic gradient Heavy metal Corbicula fluminea, Dreissena polymorpha
115 H. J. Choi, J. Ji, K. H. Chung and I. Y. Ahn 2007 Cadmium bioaccumulation and detoxification in the gill and digestive gland of the Antarctic bivalve Laternula elliptica Heavy metal Laternula elliptica
116 E. G. Reategui-Zirena, A. D. French, D. M. Klein and C. J. Salice 2017 Cadmium Compartmentalization in the Pulmonate Snail Lymnaea stagnalis: Improving Our Understanding of Exposure Heavy metal Lymnaea stagnalis
117 O. V. Podgurskaya and V. Y. Kavun 2006 Cadmium concentration and subcellular distribution in organs of the mussel Crenomytilus grayanus from upwelling regions of Okhotsk Sea and Sea of Japan Heavy metal Crenomytilus grayanus
118 P. Bustamante, R. P. Cosson, I. Gallien, F. Caurant and P. Miramand 2002 Cadmium detoxification processes in the digestive gland of cephalopods in relation to accumulated cadmium concentrations Heavy metal Loligo vulgaris
119 P. Martinez-Paz, M. Morales, P. Sanchez-Arguello, G. Morcillo and J. L. Martinez-Guitarte 2017 Cadmium in vivo exposure alters stress response and endocrine-related genes in the freshwater snail Physa acuta. New biomarker genes in a new model organism Biomarker Physa acuta
120 C. M. Ciocan and J. M. Rotchell 2004 Cadmium induction of metallothionein isoforms in juvenile and adult mussel (Mytilus edulis) Heavy metal Mytilus edulis
121 E. Hodl, E. Felder, M. Chabicovsky and R. Dallinger 2010 Cadmium stress stimulates tissue turnover in Helix pomatia: increasing cell proliferation from metal tolerance to exhaustion in molluscan midgut gland Heavy metal Helix pomatia
122 S. Pytharopoulou, G. G. Kournoutou, M. Leotsinidis, C. D. Georgiou and D. L. Kalpaxis 2013 Cadmium versus copper toxicity: insights from an integrated dissection of protein synthesis pathway in the digestive glands of mussel Mytilus galloprovincialis Heavy metal Mytilus galloprovincialis
123 J. M. Frazier 1986 Cadmium-binding proteins in the mussel, Mytilus edulis Heavy metal Mytilus edulis
124 H. C. Stone, S. B. Wilson and J. Overnell 1986 Cadmium-binding proteins in the scallop Pecten maximus Heavy metal Pecten maximus
125 Y. Dohi, K. Kosaka, K. Ohba and Y. Yoneyama 1986 Cadmium-binding proteins of three marine molluscs and characterization of two cadmium-binding glycoproteins from the hepatopancreas of a whelk, Buccinum tenuissimum Heavy metal Buccinum tenuissimum
126 P. G. Campbell, A. Giguere, E. Bonneris, L. Hare and N. Metals in the Environment Research 2005 Cadmium-handling strategies in two chronically exposed indigenous freshwater organisms--the yellow perch (Perca flavescens) and the floater mollusc (Pyganodon grandis) Heavy metal Perca flavescens, Pyganodon grandis
127 G. Roesijadi, K. M. Hansen and M. E. Fuentes 1995 Cadmium-induced expression of metallothionein and suppression of RNA to DNA ratios during molluscan development Heavy metal Crassostrea virginica
128 G. Roesijadi, K. M. Hansen and M. E. Unger 1996 Cadmium-induced metallothionein expression during embryonic and early larval development of the mollusc Crassostrea virginica Heavy metal Crassostrea virginica
129 J. Kerkvliet, T. de Boer, M. Schilthuizen and K. Kraaijeveld 2017 Candidate genes for shell colour polymorphism in Cepaea nemoralis Genetic marker Cepaea nemoralis
130 S. Perez-Rafael, F. Monteiro, R. Dallinger, S. Atrian, O. Palacios and M. Capdevila 2014 Cantareus aspersus metallothionein metal binding abilities: the unspecific CaCd/CuMT isoform provides hints about the metal preference determinants in metallothioneins Heavy metal Crassostrea hongkongensis
131 R. Caricato, M. G. Lionetto, F. Dondero, A. Viarengo and T. Schettino 2010 Carbonic anhydrase activity in Mytilus galloprovincialis digestive gland: sensitivity to heavy metal exposure Heavy metal Mytilus galloprovincialis
132 R. Dallinger, B. Lagg, M. Egg, R. Schipflinger and M. Chabicovsky 2004 Cd accumulation and Cd-metallothionein as a biomarker in Cepaea hortensis (Helicidae, Pulmonata) from laboratory exposure and metal-polluted habitats Biomarker Cepaea hortensis
133 J. Engelken and A. Hildebrandt 1999 cDNA cloning and cadmium-induced expression of metallothionein mRNA in the zebra mussel Dreissena polymorpha Heavy metal Dreissena polymorpha
134 P. Chavez-Crooker, P. Pozo, H. Castro, M. S. Dice, I. Boutet, A. Tanguy, D. Moraga and G. A. Ahearn 2003 Cellular localization of calcium, heavy metals, and metallothionein in lobster (Homarus americanus) hepatopancreas Heavy metal Homarus americanus
135 M. Niederwanger, M. Dvorak, R. Schnegg, V. Pedrini-Martha, K. Bacher, M. Bidoli and R. Dallinger 2017 Challenging the Metallothionein (MT) Gene of Biomphalaria glabrata: Unexpected Response Patterns Due to Cadmium Exposure and Temperature Stress Heavy metal Biomphalaria glabrata
136 J. P. Bourdineaud, M. Baudrimont, P. Gonzalez and J. L. Moreau 2006 Challenging the model for induction of metallothionein gene expression Heavy metal Oncorhyncus mykiss, Crassostrea gigas, Dreissena polymorpha
137 B. Zaldibar, I. Cancio, M. Soto and I. Marigomez 2008 Changes in cell-type composition in digestive gland of slugs and its influence in biomarkers following transplantation between a relatively unpolluted and a chronically metal-polluted site Biomarker Arion ater
138 T. L. Rocha, E. Bilbao, C. Cardoso, M. Soto and M. J. Bebianno 2018 Changes in metallothionein transcription levels in the mussel Mytilus galloprovincialis exposed to CdTe quantum dots Heavy metal Mytilus galloprovincialis
139 G. G. Kournoutou, S. Pytharopoulou, M. Leotsinidis and D. L. Kalpaxis 2014 Changes of polyamine pattern in digestive glands of mussel Mytilus galloprovincialis under exposure to cadmium Heavy metal Mytilus galloprovincialis
140 E. David, A. Tanguy and D. Moraga 2012 Characterisation and genetic polymorphism of metallothionein gene CgMT4 in experimental families of Pacific oyster Crassostrea gigas displaying summer mortality Genetic marker Crassostrea gigas
141 S. G. George, E. Carpene, T. L. Coombs, J. Overnell and A. Youngson 1979 Characterisation of cadmium-binding proteins from mussels, Mytilus edulis (L), exposed to cadmium Heavy metal Mytilus edulis
142 S. Santiago-Rivas, A. Moreda-Pineiro, M. del Carmen Barciela-Alonso and P. Bermejo-Barrera 2009 Characterization of raft mussels according to total trace elements and trace elements bound to metallothionein-like proteins Trace metal Mytilus galloprovincialis
143 Z. Strizak, D. Ivankovic, D. Profrock, H. Helmholz, A. M. Cindric, M. Erk and A. Prange 2014 Characterization of the cytosolic distribution of priority pollutant metals and metalloids in the digestive gland cytosol of marine mussels: seasonal and spatial variability Metal Mytilus galloprovincialis
144 J. M. Frazier, S. S. George, J. Overnell, T. L. Coombs and J. Kagi 1985 Characterization of two molecular weight classes of cadmium binding proteins from the mussel, Mytilus edulis (L.) Heavy metal Mytilus edulis
145 M. Nordberg, I. Nuottaniemi, M. G. Cherian, G. F. Nordberg, T. Kjellstrom and J. S. Garvey 1986 Characterization studies on the cadmium-binding proteins from two species of New Zealand oysters Heavy metal Ostrea lutaria, Crassostrea glomerata
146 T. Arai, T. Ikemoto, A. Hokura, Y. Terada, T. Kunito, S. Tanabe and I. Nakai 2004 Chemical forms of mercury and cadmium accumulated in marine mammals and seabirds as determined by XAFS analysis Heavy metal Callorhinus ursinus, Grampus griseus, Diomedea nigripes
147 C. Velez, R. Freitas, S. C. Antunes, A. M. Soares and E. Figueira 2016 Clams sensitivity towards As and Hg: A comprehensive assessment of native and exotic species Heavy metal Ruditapes decussatus, Ruditapes philippinarum
148 A. Tanguy and D. Moraga 2001 Cloning and characterization of a gene coding for a novel metallothionein in the Pacific oyster Crassostrea gigas (CgMT2): a case of adaptive response to metal-induced stress? Metal Crassostrea gigas
149 R. Ladhar-Chaabouni, R. Mokdad-Gargouri, F. Denis and A. Hamza-Chaffai 2009 Cloning and characterization of cDNA probes for the analysis of metallothionein gene expression in the Mediterranean bivalves: Ruditapes decussatus and Cerastoderma glaucum Gene expression Ruditapes decussatus, Cerastoderma glaucum
150 D. Barsyte, K. N. White and D. A. Lovejoy 1999 Cloning and characterization of metallothionein cDNAs in the mussel Mytilus edulis L. digestive gland Gene expression Mytilus edulis
151 M. F. Rebelo, W. C. Pfeiffer, H. da Silva, Jr. and M. O. Moraes 2003 Cloning and detection of metallothionein mRNA by RT-PCR in mangrove oysters (Crassostrea rhizophorae) Metal Crassostrea rhizophorae
152 N. Ceratto, F. Dondero, J. W. van de Loo, B. Burlando and A. Viarengo 2002 Cloning and sequencing of a novel metallothionein gene in Mytilus galloprovincialis Lam Gene expression Mytilus galloprovincialis
153 R. A. Syring, T. Hoexum Brouwer and M. Brouwer 2000 Cloning and sequencing of cDNAs encoding for a novel copper-specific metallothionein and two cadmium-inducible metallothioneins from the blue crab Callinectes sapidus Heavy metal Callinectes sapidus
154 A. Tanguy, C. Mura and D. Moraga 2001 Cloning of a metallothionein gene and characterization of two other cDNA sequences in the Pacific oyster Crassostrea gigas (CgMT1) Detoxification Crassostrea gigas
155 I. Paul-Pont, P. Gonzalez, N. Montero, X. de Montaudouin and M. Baudrimont 2012 Cloning, characterization and gene expression of a metallothionein isoform in the edible cockle Cerastoderma edule after cadmium or mercury exposure Heavy metal Cerastoderma edule
156 H. Park, I. Y. Ahn, H. J. Choi, S. H. Pyo and H. E. Lee 2007 Cloning, expression and characterization of metallothionein from the Antarctic clam Laternula elliptica Heavy metal Laternula elliptica
157 N. Siboni, M. Fine, V. Bresler and Y. Loya 2004 Coastal coal pollution increases Cd concentrations in the predatory gastropod Hexaplex trunculus and is detrimental to its health Heavy metal Hexaplex trunculus
158 T. Balbi, A. Smerilli, R. Fabbri, C. Ciacci, M. Montagna, E. Grasselli, A. Brunelli, G. Pojana, A. Marcomini, G. Gallo and L. Canesi 2014 Co-exposure to n-TiO2 and Cd2+ results in interactive effects on biomarker responses but not in increased toxicity in the marine bivalve M. galloprovincialis Biomarker Mytilus galloprovincialis
159 O. Palacios, S. Perez-Rafael, A. Pagani, R. Dallinger, S. Atrian and M. Capdevila 2014 Cognate and noncognate metal ion coordination in metal-specific metallothioneins: the Helix pomatia system as a model Heavy metal Helix pomatia
160 H. Hanana, P. Turcotte, C. Andre, C. Gagnon and F. Gagne 2017 Comparative study of the effects of gadolinium chloride and gadolinium - based magnetic resonance imaging contrast agent on freshwater mussel, Dreissena polymorpha Heavy metal Dreissena polymorpha
161 J. Pellerin and J. C. Amiard 2009 Comparison of bioaccumulation of metals and induction of metallothioneins in two marine bivalves (Mytilus edulis and Mya arenaria) Metal Mytilus edulis, Mya arenaria
162 M. J. Bebianno and M. A. Serafim 1998 Comparison of metallothionein induction in response to cadmium in the gills of the bivalve molluscs Mytilus galloprovincialis and Ruditapes decussatus Heavy metal Mytilus galloprovincialis, Ruditapes decussatus
163 F. Hispard, A. de Vaufleury, R. P. Cosson, S. Devaux, R. Scheifler, M. Coeurdassier, F. Gimbert, H. Martin, L. Richert, A. Berthelot and P. M. Badot 2008 Comparison of transfer and effects of Cd on rats exposed in a short experimental snail-rat food chain or to CdCl2 dosed food Heavy metal Helix aspersa(C. aspersus aspersus)
164 E. A. Mackay, J. Overnell, B. Dunbar, I. Davidson, P. E. Hunziker, J. H. Kagi and J. E. Fothergill 1993 Complete amino acid sequences of five dimeric and four monomeric forms of metallothionein from the edible mussel Mytilus edulis Heavy metal Mytilus edulis
165 K. M. Leung, H. Ibrahim, R. E. Dewhurst, N. J. Morley, M. Crane and J. W. Lewis 2003 Concentrations of metallothionein-like proteins and heavy metals in the freshwater snail Lymnaea stagnalis exposed to different levels of waterborne cadmium Heavy metal Lymnaea stagnalis
166 R. Bocchetti, D. Fattorini, B. Pisanelli, S. Macchia, L. Oliviero, F. Pilato, D. Pellegrini and F. Regoli 2008 Contaminant accumulation and biomarker responses in caged mussels, Mytilus galloprovincialis, to evaluate bioavailability and toxicological effects of remobilized chemicals during dredging and disposal operations in harbour areas Biomarker Mytilus galloprovincialis
167 M. Faria, D. Huertas, D. X. Soto, J. O. Grimalt, J. Catalan, M. C. Riva and C. Barata 2010 Contaminant accumulation and multi-biomarker responses in field collected zebra mussels (Dreissena polymorpha) and crayfish (Procambarus clarkii), to evaluate toxicological effects of industrial hazardous dumps in the Ebro river (NE Spain) Biomarker Dreissena polymorpha, Procambarus clarkii
168 A. Caro, G. Chereau, N. Briant, C. Roques, R. Freydier, S. Delpoux, A. Escalas and F. Elbaz-Poulichet 2015 Contrasted responses of Ruditapes decussatus (filter and deposit feeding) and Loripes lacteus (symbiotic) exposed to polymetallic contamination (Port-Camargue, France) Metal Ruditapes decussatus, Loripes lacteus
169 W. Fan, Z. Xu and W. X. Wang 2015 Contrasting metal detoxification in polychaetes, bivalves and fish from a contaminated bay Metal Neanthes japonica
170 M. Hockner, K. Stefanon, D. Schuler, R. Fantur, A. de Vaufleury and R. Dallinger 2009 Coping with cadmium exposure in various ways: the two helicid snails Helix pomatia and Cantareus aspersus share the metal transcription factor-2, but differ in promoter organization and transcription of their Cd-metallothionein genes Heavy metal Helix pomatia,
Helix aspersa
171 W. X. Wang, Y. Yang, X. Guo, M. He, F. Guo and C. Ke 2011 Copper and zinc contamination in oysters: subcellular distribution and detoxification Heavy metal Crassostrea hongkongensis, Crassostrea angulata
172 R. Dallinger, M. Chabicovsky, E. Hodl, C. Prem, P. Hunziker and C. Manzl 2005 Copper in Helix pomatia (Gastropoda) is regulated by one single cell type: differently responsive metal pools in rhogocytes Heavy metal Helix pomatia
173 A. Riveros, M. Zuniga and A. Larrain 2003 Copper metallothionein-like proteins as exposure biomarker in native and transplanted intertidal populations of the mussel Perumytilus purpuratus from San Jorge Bay, Antofagasta, Chile Biomarker Perumytilus purpuratus
174 R. Bose and S. Bhattacharya 2000 C-reactive protein in the hemolymph of Achatina fulica: interrelationship with sex steroids and metallothionein Heavy metal Achatina fulica
175 A. Viarengo, M. Lafaurie, G. P. Gabrielides, R. Fabbri, A. Marro and M. Romeo 2000 Critical evaluation of an intercalibration exercise undertaken in the framework of the MED POL biomonitoring program Biomarker Mytilus galloprovincialis
176 B. Zhang, C. D. Fang, J. H. Xu and H. J. Cao 2017 Depuration of Cadmium from Blue Mussel (Mytilus edulis) by Protein Hydrolysate-Fe(2+) Complex: The Role of Metallothionein Heavy metal Mytilus edulis
177 L. Wang and W. X. Wang 2014 Depuration of metals by the green-colored oyster Crassostrea sikamea Metal Crassostrea sikamea
178 H. Ettajani, B. Berthet, J. C. Amiard and L. Chevolot 2001 Determination of cadmium partitioning in microalgae and oysters: contribution to the assessment of trophic transfer Heavy metal Skeletonema costatum, Tetraselmis suecica,Crassostrea gigas
179 C. Tessier and J. S. Blais 1996 Determination of cadmium-metallothioneins in zebra mussels exposed to subchronic concentrations of Cd2+ Heavy metal Dreissena polymorpha
180 H. I. Falfushynska, L. L. Gnatyshyna, A. V. Ivanina, I. M. Sokolova and O. B. Stoliar 2018 Detoxification and cellular stress responses of unionid mussels Unio tumidus from two cooling ponds to combined nano-ZnO and temperature stress Heavy metal Unio tumidus
181 A. Arini, G. Daffe, P. Gonzalez, A. Feurtet-Mazel and M. Baudrimont 2014 Detoxification and recovery capacities of Corbicula fluminea after an industrial metal contamination (Cd and Zn): a one-year depuration experiment Heavy metal Corbicula fluminea
182 N. Chevre, F. Gagne and C. Blaise 2003 Development of a biomarker-based index for assessing the ecotoxic potential of aquatic sites Biomarker Mya arenaria
183 J. Voets, E. S. Redeker, R. Blust and L. Bervoets 2009 Differences in metal sequestration between zebra mussels from clean and polluted field locations Metal Dreissena polymorpha
184 F. Guo, R. Tu and W. X. Wang 2013 Different responses of abalone Haliotis discus hannai to waterborne and dietary-borne copper and zincexposure Heavy metal Haliotis discus hannai
185 D. A. Taylor, E. L. Thompson, S. V. Nair and D. A. Raftos 2013 Differential effects of metal contamination on the transcript expression of immune- and stress-response genes in the Sydney Rock oyster, Saccostrea glomerata Metal Saccostrea glomerata
186 S. Perez-Rafael, S. Atrian, M. Capdevila and O. Palacios 2011 Differential ESI-MS behaviour of highly similar metallothioneins Heavy metal Helix pomatia, Cornu aspersum
187 P. E. Baurand, V. Pedrini-Martha, A. de Vaufleury, M. Niederwanger, N. Capelli, R. Scheifler and R. Dallinger 2015 Differential expression of metallothionein isoforms in terrestrial snail embryos reflects early life stage adaptation to metal stress Metal Cantareus aspersus
188 M. Perrigault and B. Allam 2012 Differential immune response in the hard clam (mercenaria mercenaria) against bacteria and the protistan pathogen QPX (quahog parasite unknown) Biomarker Mercenaria mercenaria
189 F. Liu and W. X. Wang 2014 Differential influences of Cu and Zn chronic exposure on Cd and Hg bioaccumulation in an estuarine oyster Heavy metal Crassostrea hongkongensis
190 R. T. Lavradas, R. C. Rocha, I. C. Bordon, T. D. Saint'Pierre, J. M. Godoy and R. A. Hauser-Davis 2016 Differential metallothionein, reduced glutathione and metal levels in Perna perna mussels in two environmentally impacted tropical bays in southeastern Brazil Metal Perna perna
191 F. Liu and W. X. Wang 2011 Differential roles of metallothionein-like proteins in cadmium uptake and elimination by the scallop Chlamys nobilis Heavy metal Chlamys nobilis
192 P. E. Baurand, R. Dallinger, M. Niederwanger, N. Capelli, V. Pedrini-Martha and A. de Vaufleury 2016 Differential sensitivity of snail embryos to cadmium: relation to age and metallothionein gene expression Heavy metal Cantareus aspersus
193 R. J. Brown, T. S. Galloway, D. Lowe, M. A. Browne, A. Dissanayake, M. B. Jones and M. H. Depledge 2004 Differential sensitivity of three marine invertebrates to copper assessed using multiple biomarkers Biomarker Mytilus edulis, Patella vulgata, Carcinus maenas
194 N. J. Bouskill, R. D. Handy, T. E. Ford and T. S. Galloway 2006 Differentiating copper and arsenic toxicity using biochemical biomarkers in Asellus aquaticus and Dreissena polymorpha Heavy metal Asellus aquaticus, Dreissena polymorpha
195 A. Jimeno-Romero, E. Bilbao, U. Izagirre, M. P. Cajaraville, I. Marigomez and M. Soto 2017 Digestive cell lysosomes as main targets for Ag accumulation and toxicity in marine mussels, Mytilus galloprovincialis, exposed to maltose-stabilised Ag nanoparticles of different sizes Heavy metal Mytilus galloprovincialis
196 M. J. Jenny, A. H. Ringwood, K. Schey, G. W. Warr and R. W. Chapman 2004 Diversity of metallothioneins in the American oyster, Crassostrea virginica, revealed by transcriptomic and proteomic approaches Phylogenetic Crassostrea virginica
197 A. Chatel, V. Faucet-Marquis, A. Pfohl-Leszkowicz, C. Gourlay-France and F. Vincent-Hubert 2014 DNA adduct formation and induction of detoxification mechanisms in Dreissena polymorpha exposed to nitro-PAHs Detoxification Dreissena polymorpha
198 A. Geffard, C. Amiard-Triquet and J. C. Amiard 2005 Do seasonal changes affect metallothionein induction by metals in mussels, Mytilus edulis? Metal Mytilus edulis
199 S. Gil-Moreno, E. Jimenez-Marti, O. Palacios, O. Zerbe, R. Dallinger, M. Capdevila and S. Atrian 2015 Does Variation of the Inter-Domain Linker Sequence Modulate the Metal Binding Behaviour of Helix pomatia Cd-Metallothionein? Heavy metal Helix pomatia
200 F. Geret and M. J. Bebianno 2004 Does zinc produce reactive oxygen species in Ruditapes decussatus? Heavy metal Ruditapes decussatus
201 T. Y. Ng and W. X. Wang 2005 Dynamics of metal subcellular distribution and its relationship with metal uptake in marine mussels Metal Perna viridis
202 K. Boukadida, J. Cachot, C. Clerandeaux, P. Y. Gourves and M. Banni 2017 Early and efficient induction of antioxidant defense system in Mytilus galloprovincialis embryos exposed to metals and heat stress Antioxidant Mytilus galloprovincialis
203 A. Bigot, L. Minguez, L. Giamberini and F. Rodius 2011 Early defense responses in the freshwater bivalve Corbicula fluminea exposed to copper and cadmium: Transcriptional and histochemical studies Heavy metal Corbicula fluminea
204 B. Quinn, F. Gagne, J. P. Weber and C. Blaise 2005 Ecotoxicological effects of a semi-submerged municipal dump (Castle harbour, Bermuda) on the Calico scallop Argopecten gibbus Biomarker Argopecten gibbus
205 V. Funes, J. Alhama, J. I. Navas, J. Lopez-Barea and J. Peinado 2006 Ecotoxicological effects of metal pollution in two mollusc species from the Spanish South Atlantic littoral Metal Crassostrea angulata, Mytilus galloprovincialis
206 S. Carreira, P. M. Costa, M. Martins, J. Lobo, M. H. Costa and S. Caeiro 2013 Ecotoxicological heterogeneity in transitional coastal habitats assessed through the integration of biomarkers and sediment-contamination profiles: a case study using a commercial clam Biomarker Ruditapes decussatus
207 A. Serafim and M. J. Bebianno 2010 Effect of a polymetallic mixture on metal accumulation and metallothionein response in the clam Ruditapes decussatus Heavy metal Ruditapes decussatus
208 F. Geret, A. Serafim, L. Barreira and M. J. Bebianno 2002 Effect of cadmium on antioxidant enzyme activities and lipid peroxidation in the gills of the clam Ruditapes decussatus Biomarker Ruditapes decussatus
209 A. Devos, C. Voiseux, C. Caplat and B. Fievet 2012 Effect of chronic exposure to zinc in young spats of the Pacific oyster (Crassostrea gigas) Heavy metal Crassostrea gigas
210 A. Hamza-Chaffai, M. Romeo, M. Gnassia-Barelli and A. El Abed 1998 Effect of copper and lindane on some biomarkers measured in the clam Ruditapes decussatus Biomarker Ruditapes decussatus
211 M. Cavaletto, A. Ghezzi, B. Burlando, V. Evangelisti, N. Ceratto and A. Viarengo 2002 Effect of hydrogen peroxide on antioxidant enzymes and metallothionein level in the digestive gland of Mytilus galloprovincialis. cavalett@unipmn.it Antioxidant Mytilus galloprovincialis
212 B. Hamer, Z. Jaksic, D. Pavicic-Hamer, L. Peric, D. Medakovic, D. Ivankovic, J. Pavicic, C. Zilberberg, H. C. Schroder, W. E. Muller, N. Smodlaka and R. Batel 2008 Effect of hypoosmotic stress by low salinity acclimation of Mediterranean mussels Mytilus galloprovincialis on biological parameters used for pollution assessment Biomarker Mytilus galloprovincialis
213 H. I. Falfushynska, L. L. Gnatyshyna and O. B. Stoliar 2013 Effect of in situ exposure history on the molecular responses of freshwater bivalve Anodonta anatina (Unionidae) to trace metals Trace metal Anodonta anatina
214 E. Farcy, C. Voiseux, I. Robbes, J. M. Lebel and B. Fievet 2011 Effect of ionizing radiation on the transcription levels of cell stress marker genes in the Pacific oyster Crassostrea gigas Biomarker Crassostrea gigas
215 H. Van den Broeck, H. De Wolf, T. Backeljau and R. Blust 2010 Effect of metal accumulation on metallothionein level and condition of the periwinkle Littorina littorea along the Scheldt estuary (the Netherlands) Biomarker Littorina littorea
216 S. K. Sheir, R. D. Handy and T. B. Henry 2013 Effect of pollution history on immunological responses and organ histology in the marine mussel Mytilus edulis exposed to cadmium Heavy metal Mytilus edulis
217 C. Bataille, G. Baldacchino, R. P. Cosson, M. Coppo, C. Trehen, G. Vigneron, J. P. Renault and S. Pin 2005 Effect of pressure on pulse radiolysis reduction of proteins Heavy metal Mytilus edulis
218 F. Moschovaki-Filippidou, A. Itziou and V. K. Dimitriadis 2013 Effect of starvation and hibernation on the values of five biomarkers of general and specific stress using the land snail Eobania vermiculata Biomarker Eobania vermiculata
219 M. A. Serafim, R. M. Company, M. J. Bebianno and W. J. Langston 2002 Effect of temperature and size on metallothionein synthesis in the gill of Mytilus galloprovincialis exposed to cadmium Heavy metal Mytilus galloprovincialis
220 A. Galitsopoulou, D. Georgantelis and M. G. Kontominas 2013 Effect of thermal processing and canning on cadmium and lead levels in California market squid: the role of metallothioneins Heavy metal None
221 E. Mottin, C. Caplat, T. Latire, A. Mottier, M. L. Mahaut, K. Costil, D. Barillier, J. M. Lebel and A. Serpentini 2012 Effect of zinc sacrificial anode degradation on the defence system of the Pacific oyster, Crassostrea gigas: chronic and acute exposures Heavy metal Crassostrea gigas
222 L. Canesi, C. Borghi, R. Fabbri, C. Ciacci, L. C. Lorusso, G. Gallo and L. Vergani 2007 Effects of 17beta-estradiol on mussel digestive gland Antioxidant Mytilus galloprovincialis
223 G. Francois, D. Melanie, F. Marlene and F. Michel 2015 Effects of a municipal effluent on the freshwater mussel Elliptio complanata following challenge with Vibrio anguillarum Metal Elliptio complanata, Vibrio anguillarum
224 D. Shi, G. Blackmore and W. X. Wang 2003 Effects of aqueous and dietary preexposure and resulting body burden on silver biokinetics in the green mussel Perma viridis Heavy metal Perma viridis
225 A. V. Ivanina, A. S. Cherkasov and I. M. Sokolova 2008 Effects of cadmium on cellular protein and glutathione synthesis and expression of stress proteins in eastern oysters, Crassostrea virginica Gmelin Heavy metal Crassostrea virginica
226 P. J. den Besten, P. T. Bosma, H. J. Herwig, D. I. Zandee and P. A. Voogt 1991 Effects of cadmium on metal composition and adenylate energy charge in the sea star Asterias rubens L Heavy metal Asterias rubens
227 C. Peyrot, C. Gagnon, F. Gagne, K. J. Willkinson, P. Turcotte and S. Sauve 2009 Effects of cadmium telluride quantum dots on cadmium bioaccumulation and metallothionein production to the freshwater mussel, Elliptio complanata Heavy metal Elliptio complanata
228 T. Gomes, J. P. Pinheiro, I. Cancio, C. G. Pereira, C. Cardoso and M. J. Bebianno 2011 Effects of copper nanoparticles exposure in the mussel Mytilus galloprovincialis Heavy metal Mytilus galloprovincialis
229 C. A. Hawkins and I. M. Sokolova 2017 Effects of elevated CO2 levels on subcellular distribution of trace metals (Cd and Cu) in marine bivalves Heavy metal Mercenaria mercenaria
230 A. V. Ivanina, C. Taylor and I. M. Sokolova 2009 Effects of elevated temperature and cadmium exposure on stress protein response in eastern oysters Crassostrea virginica (Gmelin) Heavy metal Crassostrea virginica
231 A. V. Ivanina, C. Hawkins, E. Beniash and I. M. Sokolova 2015 Effects of environmental hypercapnia and metal (Cd and Cu) exposure on acid-base and metal homeostasis of marine bivalves Heavy metal Crassostrea virginica, Mercenaria mercenaria
232 K. K. Lehtonen and S. Leinio 2003 Effects of exposure to copper and malathion on metallothionein levels and acetylcholinesterase activity of the mussel Mytilus edulis and the clam Macoma balthica from the northern Baltic Sea Heavy metal Mytilus edulis, Macoma balthica
233 M. Cong, H. Wu, X. Liu, J. Zhao, X. Wang, J. Lv and L. Hou 2012 Effects of heavy metals on the expression of a zinc-inducible metallothionein-III gene and antioxidant enzyme activities in Crassostrea gigas Biomarker Crassostrea gigas
234 N. Kamel, T. Burgeot, M. Banni, M. Chalghaf, S. Devin, C. Minier and H. Boussetta 2014 Effects of increasing temperatures on biomarker responses and accumulation of hazardous substances in rope mussels (Mytilus galloprovincialis) from Bizerte lagoon Biomarker Mytilus galloprovincialis
235 A. Itziou and V. K. Dimitriadis 2012 Effects of organic pollutants on Eobania vermiculata measured with five biomarkers Biomarker Eobania vermiculata
236 J. F. Oaten, M. D. Hudson, A. C. Jensen and I. D. Williams 2015 Effects of organism preparation in metallothionein and metal analysis in marine invertebrates for biomonitoring marine pollution Biomarker Mytilus edulis
237 A. Giannetto, M. Maisano, T. Cappello, S. Oliva, V. Parrino, A. Natalotto, G. De Marco and S. Fasulo 2017 Effects of Oxygen Availability on Oxidative Stress Biomarkers in the Mediterranean Mussel Mytilus galloprovincialis Biomarker Mytilus galloprovincialis
238 T. Gomes, C. G. Pereira, C. Cardoso, V. S. Sousa, M. R. Teixeira, J. P. Pinheiro and M. J. Bebianno 2014 Effects of silver nanoparticles exposure in the mussel Mytilus galloprovincialis Heavy metal Mytilus galloprovincialis
239 F. Hispard, A. de Vaufleury, H. Martin, S. Devaux, R. P. Cosson, R. Scheifler, L. Richert, A. Berthelot and P. M. Badot 2008 Effects of subchronic digestive exposure to organic or inorganic cadmium on biomarkers in rat tissues Biomarker Helix aspersa
240 A. Mottier, A. Seguin, A. Devos, C. L. Pabic, C. Voiseux, J. M. Lebel, A. Serpentini, B. Fievet and K. Costil 2015 Effects of subchronic exposure to glyphosate in juvenile oysters (Crassostrea gigas): From molecular to individual levels Biomarker Crassostrea gigas
241 C. Ciacci, C. Barmo, G. Gallo, M. Maisano, T. Cappello, A. D'Agata, C. Leonzio, A. Mauceri, S. Fasulo and L. Canesi 2012 Effects of sublethal, environmentally relevant concentrations of hexavalent chromium in the gills of Mytilus galloprovincialis Heavy metal Mytilus galloprovincialis
242 B. Quinn, W. Schmidt, K. O'Rourke and R. Hernan 2011 Effects of the pharmaceuticals gemfibrozil and diclofenac on biomarker expression in the zebra mussel (Dreissena polymorpha) and their comparison with standardised toxicity tests Biomarker Dreissena polymorpha
243 W. Schmidt, K. O'Rourke, R. Hernan and B. Quinn 2011 Effects of the pharmaceuticals gemfibrozil and diclofenac on the marine mussel (Mytilus spp.) and their comparison with standardized toxicity tests Biomarker Mytilus spp.
244 H. Attig, N. Kamel, S. Sforzini, A. Dagnino, J. Jamel, H. Boussetta, A. Viarengo and M. Banni 2014 Effects of thermal stress and nickel exposure on biomarkers responses in Mytilus galloprovincialis (Lam) Biomarker Mytilus galloprovincialis
245 F. Gagne, P. Turcotte, M. Pilote, J. Auclair, C. Andre and C. Gagnon 2016 Elemental profiles of freshwater mussels treated with silver nanoparticles: A metallomic approach Heavy metal Elliptio complanata
246 F. Gagne, C. Blaise and J. Hellou 2004 Endocrine disruption and health effects of caged mussels, Elliptio complanata, placed downstream from a primary-treated municipal effluent plume for 1 year Gene expression Elliptio complanata
247 A. D'Agata, S. Fasulo, L. J. Dallas, A. S. Fisher, M. Maisano, J. W. Readman and A. N. Jha 2014 Enhanced toxicity of 'bulk' titanium dioxide compared to 'fresh' and 'aged' nano-TiO2 in marine mussels (Mytilus galloprovincialis) Gene expression Mytilus galloprovincialis
248 C. Pirrone, F. Rossi, S. Cappello, M. Borgese, G. Mancini, G. Bernardini and R. Gornati 2018 Evaluation of biomarkers in Mytilus galloprovincialis as an integrated measure of biofilm-membrane bioreactor (BF-MBR) system efficiency in mitigating the impact of oily wastewater discharge to marine environment: a microcosm approach Biomarker Mytilus galloprovincialis
249 H. Falfushynska, L. Gnatyshyna, O. Stoliar, N. Mitina, T. Skorokhoda, Y. Filyak, A. Zaichenko and R. Stoika 2012 Evaluation of biotargeting and ecotoxicity of Co(2)(+)-containing nanoscale polymeric complex by applying multi-marker approach in bivalve mollusk Anodonta cygnea Toxicity Anodonta cygnea
250 R. Scudiero, P. Creti, F. Trinchella and M. Grazia Esposito 2014 Evaluation of cadmium, lead and metallothionein contents in the tissues of mussels (Mytilus galloprovincialis) from the Campania coast (Italy): levels and seasonal trends Heavy metal Mytilus galloprovincialis
251 S. Lecoeur, B. Videmann and P. Berny 2004 Evaluation of metallothionein as a biomarker of single and combined Cd/Cu exposure in Dreissena polymorpha Biomarker Dreissena polymorpha
252 S. Pytharopoulou, E. C. Kouvela, E. Sazakli, M. Leotsinidis and D. L. Kalpaxis 2006 Evaluation of the global protein synthesis in Mytilus galloprovincialis in marine pollution monitoring: seasonal variability and correlations with other biomarkers Biomarker Mytilus galloprovincialis
253 D. Ivankovic, J. Pavicic, M. Erk, V. Filipovic-Marijic and B. Raspor 2005 Evaluation of the Mytilus galloprovincialis Lam. digestive gland metallothionein as a biomarker in a long-term field study: seasonal and spatial variability Biomarker Mytilus galloprovincialis
254 E. J. Won, S. Hong, K. Ra, K. T. Kim and K. H. Shin 2011 Evaluation of the potential impact of polluted sediments using Manila clam Ruditapes philippinarum: bioaccumulation and biomarker responses Biomarker Ruditapes philippinarum
255 J. Lobo, P. M. Costa, S. Caeiro, M. Martins, A. M. Ferreira, M. Caetano, R. Cesario, C. Vale and M. H. Costa 2010 Evaluation of the potential of the common cockle (Cerastoderma edule L.) for the ecological risk assessment of estuarine sediments: bioaccumulation and biomarkers Biomarker Cerastoderma edule
256 M. Baudrimont and X. de Montaudouin 2007 Evidence of an altered protective effect of metallothioneins after cadmium exposure in the digenean parasite-infected cockle (Cerastoderma edule) Heavy metal Cerastoderma edule
257 P. L. Gillis, S. K. Higgins and M. B. Jorge 2014 Evidence of oxidative stress in wild freshwater mussels (Lasmigona costata) exposed to urban-derived contaminants Biomarker Lasmigona costata
258 B. Raspor, Z. Dragun and M. Erk 2005 Examining the suitability of mussel digestive gland to serve as a biomonitoring target organ Biomarker Mytilus galloprovincialis
259 C. Gagnon, F. Gagne, P. Turcotte, I. Saulnier, C. Blaise, M. H. Salazar and S. M. Salazar 2006 Exposure of caged mussels to metals in a primary-treated municipal wastewater plume Metal Elliptio complanata
260 S. Franzellitti, S. Buratti, F. Donnini and E. Fabbri 2010 Exposure of mussels to a polluted environment: insights into the stress syndrome development Biomarker Mytilus galloprovincialis
261 T. C. Hoang and G. M. Rand 2009 Exposure routes of copper: short term effects on survival, weight, and uptake in Florida apple snails (Pomacea paludosa) Heavy metal Pomacea paludosa
262 V. Contardo-Jara, C. Lorenz, S. Pflugmacher, G. Nutzmann, W. Kloas and C. Wiegand 2011 Exposure to human pharmaceuticals Carbamazepine, Ibuprofen and Bezafibrate causes molecular effects in Dreissena polymorpha Biomarker Dreissena polymorpha
263 A. M. Taylor and W. A. Maher 2012 Exposure-dose-response of Anadara trapezia to metal contaminated estuarine sediments. 1. Cadmium spiked sediments Heavy metal Anadara trapezia
264 A. M. Taylor and W. A. Maher 2012 Exposure-dose-response of Anadara trapezia to metal contaminated estuarine sediments. 2. Lead spiked sediments Metal Anadara trapezia
265 A. M. Taylor and W. A. Maher 2014 Exposure-dose-response of Tellina deltoidalis to contaminated estuarine sediments 3. Selenium spiked sediments Metal Tellina deltoidalis
266 A. M. Taylor and W. A. Maher 2014 Exposure-dose-response of Tellina deltoidalis to metal contaminated estuarine sediments 2. Lead spiked sediments Metal Tellina deltoidalis
267 C. P. Marasinghe Wadige, W. A. Maher, A. M. Taylor and F. Krikowa 2014 Exposure-dose-response relationships of the freshwater bivalve Hyridella australis to cadmium spiked sediments Heavy metal Hyridella australis
268 A. Piano, P. Valbonesi and E. Fabbri 2004 Expression of cytoprotective proteins, heat shock protein 70 and metallothioneins, in tissues of Ostrea edulis exposed to heat and heavy metals Heavy metal Ostrea edulis
269 S. Fasulo, A. Mauceri, A. Giannetto, M. Maisano, N. Bianchi and V. Parrino 2008 Expression of metallothionein mRNAs by in situ hybridization in the gills of Mytilus galloprovincialis, from natural polluted environments Heavy metal Mytilus galloprovincialis
270 M. Grattarola, M. Carloni, F. Dondero, A. Viarengo and L. Vergani 2006 Expression, purification and preliminary characterization of mussel (Mytilus galloprovincialis) metallothionein MT20 Metal Mytilus galloprovincialis
271 F. Liu and W. X. Wang 2013 Facilitated bioaccumulation of cadmium and copper in the oyster Crassostrea hongkongensis solely exposed to zinc Heavy metal Crassostrea hongkongensis
272 P. E. Buffet, C. Amiard-Triquet, A. Dybowska, C. Risso-de Faverney, M. Guibbolini, E. Valsami-Jones and C. Mouneyrac 2012 Fate of isotopically labeled zinc oxide nanoparticles in sediment and effects on two endobenthic species, the clam Scrobicularia plana and the ragworm Hediste diversicolor Heavy metal Scrobicularia plana, Hediste diversicolor
273 A. Rabei, A. Hichami, H. Beldi, S. Bellenger, N. A. Khan and N. Soltani 2018 Fatty acid composition, enzyme activities and metallothioneins in Donax trunculus (Mollusca, Bivalvia) from polluted and reference sites in the Gulf of Annaba (Algeria): Pattern of recovery during transplantation Biomarker Donax trunculus
274 M. L. Martin-Diaz, J. Blasco, D. Sales and T. A. Delvalls 2008 Field validation of a battery of biomarkers to assess sediment quality in Spanish ports Biomarker Carcinus maenas, Ruditapes philippinarum
275 L. Vergani, M. Grattarola, C. Borghi, F. Dondero and A. Viarengo 2005 Fish and molluscan metallothioneins Metal Mytilus galloprovincialis, Oncorhyncus mykiss
276 T. E. English and K. B. Storey 2003 Freezing and anoxia stresses induce expression of metallothionein in the foot muscle and hepatopancreas of the marine gastropod Littorina littorea Antioxidant Littorina littorea
277 F. Dondero, L. Piacentini, F. Marsano, M. Rebelo, L. Vergani, P. Venier and A. Viarengo 2006 Gene transcription profiling in pollutant exposed mussels (Mytilus spp.) using a new low-density oligonucleotide microarray Biomarker Mytilus galloprovincialis, Mytilus edulis
278 D. Moraga, E. Mdelgi-Lasram, M. S. Romdhane, A. El Abed, I. Boutet, A. Tanguy and M. Auffret 2002 Genetic responses to metal contamination in two clams: Ruditapes decussatus and Ruditapes philippinarum Metal Ruditapes decussatus, Ruditapes philippinarum
279 A. Chatel, V. Faucet-Marquis, C. Gourlay-France, A. Pfohl-Leszkowicz and F. Vincent-Hubert 2015 Genotoxicity and activation of cellular defenses in transplanted zebra mussels Dreissena polymorpha along the Seine river Biomarker Dreissena polymorpha
280 C. Bolognesi, E. Landini, P. Roggieri, R. Fabbri and A. Viarengo 1999 Genotoxicity biomarkers in the assessment of heavy metal effects in mussels: experimental studies Biomarker Mytilus galloprovincialis
281 G. Zaroogian and C. Norwood 2002 Glutathione and metallothionein status in an acute response by Mercenaria mercenaria brown cells to copper in vivo Heavy metal Mercenaria mercenaria
282 H. Falfushynska, L. Gnatyshyna, I. Yurchak, A. Ivanina, O. Stoliar and I. Sokolova 2014 Habitat pollution and thermal regime modify molecular stress responses to elevated temperature in freshwater mussels (Anodonta anatina: Unionidae) Antioxidant Anodonta anatina
283 A. Hamza-Chaffai, J. Pellerin and J. C. Amiard 2003 Health assessment of a marine bivalve Ruditapes decussatus from the Gulf of Gabes (Tunisia) Biomarker Ruditapes decussatus
284 A. G. Howard and G. Nickless 1977 Heavy metal complexation in polluted molluscs II. Oysters (Ostrea edulis and Crassostrea gigas) Heavy metal Ostrea edulis, Crassostrea gigas
285 A. G. Howard and G. Nickless 1977 Heavy metal complexation in polluted molluscs. I. Limpets (Patella vulgata and Patella intermedia) Heavy metal Patella vulgata and Patella intermedia
286 S. G. George 1983 Heavy metal detoxication in the mussel Mytilus edulis-composition of Cd-containing kidney granules (tertiary lysosomes) Heavy metal Mytilus edulis
287 O. S. Okay, M. Ozmen, A. Gungordu, A. Yilmaz, S. D. Yakan, B. Karacik, B. Tutak and K. W. Schramm 2016 Heavy metal pollution in sediments and mussels: assessment by using pollution indices and metallothionein levels Heavy metal Mytilus galloprovincialis
288 Y. H. Wong, J. Sun, L. S. He, L. G. Chen, J. W. Qiu and P. Y. Qian 2015 High-throughput transcriptome sequencing of the cold seep mussel Bathymodiolus platifrons Phylogenetic Bathymodiolus platifrons
289 T. T. Y. Le, S. Zimmermann and B. Sures 2016 How does the metallothionein induction in bivalves meet the criteria for biomarkers of metal exposure? Biomarker Mytilus galloprovincialis
290 I. Paul-Pont, X. de Montaudouin, P. Gonzalez, P. Soudant and M. Baudrimont 2010 How life history contributes to stress response in the Manila clam Ruditapes philippinarum Heavy metal Ruditapes philippinarum
291 E. Gourgou, I. K. Aggeli, I. Beis and C. Gaitanaki 2010 Hyperthermia-induced Hsp70 and MT20 transcriptional upregulation are mediated by p38-MAPK and JNKs in Mytilus galloprovincialis (Lamarck); a pro-survival response Biomarker Mytilus galloprovincialis
292 M. C. Milcent, F. Goudard, J. P. Durand, P. Germain, J. Pieri and S. G. George 1996 Identification of 137Cs-and 241Am-binding sites in the oyster Crassostrea gigas Heavy metal Crassostrea gigas
293 Y. Gueguen, J. P. Cadoret, D. Flament, C. Barreau-Roumiguiere, A. L. Girardot, J. Garnier, A. Hoareau, E. Bachere and J. M. Escoubas 2003 Immune gene discovery by expressed sequence tags generated from hemocytes of the bacteria-challenged oyster, Crassostrea gigas Detoxification Crassostrea gigas
294 A. Legeay, M. Achard-Joris, M. Baudrimont, J. C. Massabuau and J. P. Bourdineaud 2005 Impact of cadmium contamination and oxygenation levels on biochemical responses in the Asiatic clam Corbicula fluminea Heavy metal Corbicula fluminea
295 M. Baudrimont, X. de Montaudouin and A. Palvadeau 2006 Impact of digenean parasite infection on metallothionein synthesis by the cockle (Cerastoderma edule): a multivariate field monitoring Heavy metal Cerastoderma edule
296 C. Gagnon, P. Turcotte, S. Trepanier, F. Gagne and P. J. Cejka 2014 Impacts of municipal wastewater oxidative treatments: changes in metal physical speciation and bioavailability Metal Crassostrea sikamea
297 F. Gagne, C. Blaise, J. Pellerin, M. Fournier, C. Gagnon, J. Sherry and A. Talbot 2009 Impacts of pollution in feral Mya arenaria populations: the effects of clam bed distance from the shore Biomarker Mya arenaria
298 N. Weng and W. X. Wang 2014 Improved tolerance of metals in contaminated oyster larvae Metal Crassostrea sikamea
299 H. I. Falfushynska, L. L. Gnatyshyna and O. B. Stoliar 2013 In situ exposure history modulates the molecular responses to carbamate fungicide Tattoo in bivalve mollusk Antioxidant Anodonta anatina
300 C. Corporeau and M. Auffret 2003 In situ hybridisation for flow cytometry: a molecular method for monitoring stress-gene expression in hemolymph cells of oysters Biomarker Ostrea edulis
301 W. Smaoui-Damak, B. Berthet and A. Hamza-Chaffai 2009 In situ potential use of metallothionein as a biomarker of cadmium contamination in Ruditapes decussatus Biomarker Ruditapes decussatus
302 G. Zaroogian and E. Jackim 2000 In vivo metallothionein and glutathione status in an acute response to cadmium in Mercenaria mercenaria brown cells Heavy metal Mercenaria mercenaria
303 A. Nardi, L. F. Mincarelli, M. Benedetti, D. Fattorini, G. d'Errico and F. Regoli 2017 Indirect effects of climate changes on cadmium bioavailability and biological effects in the Mediterranean mussel Mytilus galloprovincialis Heavy metal Mytilus galloprovincialis
304 D. Ivankovic, J. Pavicic, V. Beatovic, R. S. Klobucar and G. I. Klobucar 2010 Inducibility of metallothionein biosynthesis in the whole soft tissue of zebra mussels Dreissena polymorpha exposed to cadmium, copper, and pentachlorophenol Heavy metal Dreissena polymorpha
305 J. I. Alonso and M. C. Martin-Mateo 1996 Induction and characterization of metallothionein in different organs of Ostrea edulis L Heavy metal Ostrea edulis
306 M. K. Chan, R. Othman, D. Zubir and S. Salmijah 2002 Induction of a putative metallothionein gene in the blood cockle, Anadara granosa, exposed to cadmium Heavy metal Anadara granosa
307 K. M. Leung and R. W. Furness 1999 Induction of metallothionein in dogwhelk Nucella lapillus during and after exposure to cadmium Heavy metal Nucella lapillus
308 M. T. Znidaric, I. Falnoga, M. Skreblin and V. Turk 2006 Induction of metallothionein-like proteins by mercury and distribution of mercury and selenium in the cells of hepatopancreas and gill tissues in mussel Mytilus galloprovincialis Heavy metal Mytilus galloprovincialis
309 F. Geret and R. P. Cosson 2002 Induction of specific isoforms of metallothionein in mussel tissues after exposure to cadmium or mercury Heavy metal Mytilus edulis
310 S. Cooper, E. Bonneris, A. Michaud, B. Pinel-Alloul and P. G. Campbell 2013 Influence of a step-change in metal exposure (Cd, Cu, Zn) on metal accumulation and subcellular partitioning in a freshwater bivalve, Pyganodon grandis: a long-term transplantation experiment between lakes with contrasting ambient metal levels Heavy metal Pyganodon grandis
311 J. C. Amiard, R. Journel and H. Bacheley 2008 Influence of field and experimental exposure of mussels (Mytilus sp.) to nickel and vanadium on metallothionein concentration Heavy metal Mytilus sp.
312 W. X. Wang and P. S. Rainbow 2005 Influence of metal exposure history on trace metal uptake and accumulation by marine invertebrates Trace metal Ruditapes philippinarum, Perna viridis, Balanus amphitrite
313 M. J. Bebianno, C. G. Pereira, F. Rey, A. Cravo, D. Duarte, G. D'Errico and F. Regoli 2015 Integrated approach to assess ecosystem health in harbor areas Biomarker Mytilus galloprovincialis
314 A. Gomiero, L. Da Ros, C. Nasci, F. Meneghetti, A. Spagnolo and G. Fabi 2011 Integrated use of biomarkers in the mussel Mytilus galloprovincialis for assessing off-shore gas platforms in the Adriatic Sea: results of a two-year biomonitoring program Biomarker Mytilus galloprovincialis
315 A. P. Rodrigo, P. M. Costa, M. H. Costa and S. Caeiro 2013 Integration of sediment contamination with multi-biomarker responses in a novel potential bioindicator (Sepia officinalis) for risk assessment in impacted estuaries Biomarker Sepia officinalis
316 T. Y. Ng and W. X. Wang 2007 Interactions of silver, cadmium, and copper accumulation in green mussels (Perna viridis) Heavy metal Perna viridis
317 S. Gotze, O. B. Matoo, E. Beniash, R. Saborowski and I. M. Sokolova 2014 Interactive effects of CO(2) and trace metals on the proteasome activity and cellular stress response of marine bivalves Crassostrea virginica and Mercenaria mercenaria Trace metal Crassostrea virginica, Mercenaria mercenaria
318 I. Paul-Pont, X. de Montaudouin, P. Gonzalez, F. Jude, N. Raymond, C. Paillard and M. Baudrimont 2010 Interactive effects of metal contamination and pathogenic organisms on the introduced marine bivalve Ruditapes philippinarum in European populations Metal Ruditapes philippinarum
319 I. Paul-Pont, P. Gonzalez, M. Baudrimont, F. Jude, N. Raymond, L. Bourrasseau, N. Le Goic, F. Haynes, A. Legeay, C. Paillard and X. de Montaudouin 2010 Interactive effects of metal contamination and pathogenic organisms on the marine bivalve Cerastoderma edule Metal Cerastoderma edule
320 C. Gonzalez-Fernandez, M. Albentosa and I. Sokolova 2017 Interactive effects of nutrition, reproductive state and pollution on molecular stress responses of mussels, Mytilus galloprovincialis Lamarck, 1819 Biomarker Mytilus galloprovincialis
321 H. Falfushynska, L. Gnatyshyna, I. Yurchak, O. Stoliar and I. M. Sokolova 2016 Interpopulational variability of molecular responses to ionizing radiation in freshwater bivalves Anodonta anatina (Unionidae) Biomarker Anodonta anatina
322 E. K. Raftopoulou, S. Dailianis, V. K. Dimitriadis and M. Kaloyianni 2006 Introduction of cAMP and establishment of neutral lipids alterations as pollution biomarkers using the mussel Mytilus galloprovincialis. Correlation with a battery of biomarkers Biomarker Mytilus galloprovincialis
323 A. Itziou and V. K. Dimitriadis 2011 Introduction of the land snail Eobania vermiculata as a bioindicator organism of terrestrial pollution using a battery of biomarkers Biomarker Eobania vermiculata
324 V. Tsarpali and S. Dailianis 2012 Investigation of landfill leachate toxic potency: an integrated approach with the use of stress indices in tissues of mussels Biomarker Mytilus galloprovincialis
325 M. J. Bebianno, M. A. Serafim and M. F. Rita 1994 Involvement of metallothionein in cadmium accumulation and elimination in the clam Ruditapes decussata Heavy metal Ruditapes decussata
326 A. Serafim and M. J. Bebianno 2007 Involvement of metallothionein in Zn accumulation and elimination strategies in Ruditapes decussatus Heavy metal Ruditapes decussatus
327 D. Macias-Mayorga, I. Laiz, I. Moreno-Garrido and J. Blasco 2015 Is oxidative stress related to cadmium accumulation in the Mollusc Crassostrea angulata? Heavy metal Crassostrea angulata
328 B. Raspor, Z. Dragun, M. Erk, D. Ivankovic and J. Pavicic 2004 Is the digestive gland of Mytilus galloprovincialis a tissue of choice for estimating cadmium exposure by means of metallothioneins? Heavy metal Mytilus galloprovincialis
329 R. Dallinger, M. Chabicovsky and B. Berger 2004 Isoform-specific quantification of metallothionein in the terrestrial gastropod Helix pomatia. I. Molecular, biochemical, and methodical background Biomarker Helix pomatia
330 R. Dallinger, M. Chabicovsky, B. Lagg, R. Schipflinger, H. G. Weirich and B. Berger 2004 Isoform-specific quantification of metallothionein in the terrestrial gastropod Helix pomatia. II. A differential biomarker approach under laboratory and field conditions Biomarker Helix pomatia
331 P. T. Leung, T. J. Park, Y. Wang, C. M. Che and K. M. Leung 2014 Isoform-specific responses of metallothioneins in a marine pollution biomonitor, the green-lipped mussel Perna viridis, towards different stress stimulations Biomarker Perna viridis
332 D. C. Simes, M. J. Bebianno and J. J. Moura 2003 Isolation and characterisation of metallothionein from the clam Ruditapes decussatus Biomarker Ruditapes decussatus
333 C. L. Chou, R. D. Guy and J. F. Uthe 1991 Isolation and characterization of metal-binding proteins (metallothioneins) from lobster digestive gland (Homarus americanus) Heavy metal Homarus americanus
334 V. Leignel and M. Laulier 2006 Isolation and characterization of Mytilus edulis metallothionein genes MT gene Mytilus edulis
335 B. A. Fowler and M. M. Megginson 1986 Isolation and partial characterization of a high molecular weight Cd/Zn-binding protein from the kidney of the scallop Placopecten magellanicus: preliminary studies Heavy metal Placopecten magellanicus
336 A. Serafim and M. J. Bebianno 2007 Kinetic model of cadmium accumulation and elimination and metallothionein response in Ruditapes decussatus Heavy metal Ruditapes decussatus
337 R. P. Sharma 1983 Ligands binding cadmium, zinc, and copper in a species of New Zealand oyster (Ostrea lutaria) Heavy metal Ostrea chilensis
338 W. Aly, I. D. Williams and M. D. Hudson 2014 Limitations of metallothioneins in common cockles (Cerastoderma edule) and sponges (Haliclona oculata) as biomarkers of metal contamination in a semi-enclosed coastal area Biomarker Cerastoderma edule, Haliclona oculata
339 O. Perceval, Y. Couillard, B. Pinel-Alloul and P. G. Campbell 2006 Linking changes in subcellular cadmium distribution to growth and mortality rates in transplanted freshwater bivalves (Pyganodon grandis) Heavy metal Pyganodon grandis
340 M. Chabicovsky, H. Niederstatter, R. Thaler, E. Hodl, W. Parson, W. Rossmanith and R. Dallinger 2003 Localization and quantification of Cd- and Cu-specific metallothionein isoform mRNA in cells and organs of the terrestrial gastropod Helix pomatia Heavy metal Helix pomatia
341 O. Perceval, Y. Couillard, B. Pinel-Alloul, E. Bonneris and P. G. Campbell 2006 Long-term trends in accumulated metals (Cd, Cu and Zn) and metallothionein in bivalves from lakes within a smelter-impacted region Heavy metal Pyganodon grandis
342 R. Freitas, E. Costa, C. Velez, J. Santos, A. Lima, C. Oliveira, A. Maria Rodrigues, V. Quintino and E. Figueira 2012 Looking for suitable biomarkers in benthic macroinvertebrates inhabiting coastal areas with low metal contamination: comparison between the bivalve Cerastoderma edule and the Polychaete Diopatra neapolitana Biomarker Cerastoderma edule, Diopatra neapolitana
343 G. P. Domouhtsidou, S. Dailianis, M. Kaloyianni and V. K. Dimitriadis 2004 Lysosomal membrane stability and metallothionein content in Mytilus galloprovincialis (L.), as biomarkers. Combination with trace metal concentrations Biomarker Mytilus galloprovincialis
344 S. Petrovic, B. Ozretic, M. Krajnovic-Ozretic and D. Bobinac 2001 Lysosomal membrane stability and metallothioneins in digestive gland of Mussels (Mytilus galloprovincialis Lam.) as biomarkers in a field study Biomarker Mytilus galloprovincialis
345 L. Da Ros, V. Moschino, S. Guerzoni and H. P. Halldorsson 2007 Lysosomal responses and metallothionein induction in the blue mussel Mytilus edulis from the south-west coast of Iceland Biomarker Mytilus edulis
346 F. Quiniou, G. Damiens, M. Gnassia-Barelli, A. Geffard, C. Mouneyrac, H. Budzinski and M. Romeo 2007 Marine water quality assessment using transplanted oyster larvae Biomarker Crassostrea gigas
347 B. Berger, P. E. Hunziker, C. R. Hauer, N. Birchler and R. Dallinger 1995 Mass spectrometry and amino acid sequencing of two cadmium-binding metallothionein isoforms from the terrestrial gastropod Arianta arbustorum Heavy metal Arianta arbustorum
348 J. Kopecka, K. K. Lehtonen, J. Barsiene, K. Broeg, P. J. Vuorinen, J. Gercken and J. Pempkowiak 2006 Measurements of biomarker levels in flounder (Platichthys flesus) and blue mussel (Mytilus trossulus) from the Gulf of Gdansk (southern Baltic) Biomarker Platichthys flesus, Mytilus trossulus
349 M. Chabicovsky, W. Klepal and R. Dallinger 2004 Mechanisms of cadmium toxicity in terrestrial pulmonates: programmed cell death and metallothionein overload Heavy metal Helix pomatia
350 T. Y. Ng, N. M. Pais and C. M. Wood 2011 Mechanisms of waterborne Cu toxicity to the pond snail Lymnaea stagnalis: physiology and Cu bioavailability Heavy metal Lymnaea stagnalis
351 A. Leomanni, T. Schettino, A. Calisi and M. G. Lionetto 2016 Mercury induced haemocyte alterations in the terrestrial snail Cantareus apertus as novel biomarker Biomarker Cantareus apertus
352 E. Marafante, C. Nolan and G. Lorenzon 1985 Metabolism in the rat of cadmium biocomplexes from edible mussel exposed to 109CdCl2 Heavy metal Mytilus galloprovincialis
353 P. Irato, G. Santovito, A. Cassini, E. Piccinni and V. Albergoni 2003 Metal accumulation and binding protein induction in Mytilus galloprovincialis, Scapharca inaequivalvis, and Tapes philippinarum from the Lagoon of Venice Metal Mytilus galloprovincialis, Scapharca inaequivalvis, Tapes philippinarum
354 L. Luo, C. Ke, X. Guo, B. Shi and M. Huang 2014 Metal accumulation and differentially expressed proteins in gill of oyster (Crassostrea hongkongensis) exposed to long-term heavy metal-contaminated estuary Heavy metal Crassostrea hongkongensis
355 G. Santovito, F. Boldrin and P. Irato 2015 Metal and metallothionein distribution in different tissues of the Mediterranean clam Venerupis philippinarum during copper treatment and detoxification Heavy metal Venerupis philippinarum
356 Z. Dragun, M. Erk, B. Raspor, D. Ivankovic and J. Pavicic 2004 Metal and metallothionein level in the heat-treated cytosol of gills of transplanted mussels Mytilus galloprovincialis Lmk Heavy metal Mytilus galloprovincialis
357 M. Pilote, C. Andre, P. Turcotte, F. Gagne and C. Gagnon 2018 Metal bioaccumulation and biomarkers of effects in caged mussels exposed in the Athabasca oil sands area Biomarker Pyganodon grandis
358 G. Damiens, C. Mouneyrac, F. Quiniou, E. His, M. Gnassia-Barelli and M. Romeo 2006 Metal bioaccumulation and metallothionein concentrations in larvae of Crassostrea gigas Biomarker Crassostrea gigas
359 F. Guo, Y. Yang and W. X. Wang 2013 Metal bioavailability from different natural prey to a marine predator Nassarius siquijorensis Metal Nassarius siquijorensis
360 E. Strogyloudi, M. O. Angelidis, A. Christides and E. Papathanassiou 2012 Metal concentrations and metallothionein levels in Mytilus galloprovincialis from Elefsis bay (Saronikos gulf, Greece) Heavy metal Mytilus galloprovincialis
361 M. A. Bighiu, E. Gorokhova, B. Carney Almroth and A. K. Eriksson Wiklund 2017 Metal contamination in harbours impacts life-history traits and metallothionein levels in snails Biomarker Theodoxus fluviatilis
362 F. Hispard, D. Schuler, A. de Vaufleury, R. Scheifler, P. M. Badot and R. Dallinger 2008 Metal distribution and metallothionein induction after cadmium exposure in the terrestrial snail Helix aspersa (Gastropoda, Pulmonata) Heavy metal Helix aspersa
363 Y. Hardivillier, F. Denis, M. V. Demattei, P. Bustamante, M. Laulier and R. Cosson 2006 Metal influence on metallothionein synthesis in the hydrothermal vent mussel Bathymodiolus thermophilus Heavy metal Bathymodiolus thermophilus
364 B. E. Imber, J. A. Thompson and S. Ward 1987 Metal-binding protein in the Pacific oyster, Crassostrea gigas: assessment of the protein as a biochemical environmental indicator Metal Crassostrea gigas
365 H. F. Hennig 1986 Metal-binding proteins as metal pollution indicators Metal Jasus lalandii, Diogenes brevirostris, Palaemon pacificus, Choromytilus meridionalis,  Patella granularis
366 O. Perceval, Y. Couillard, B. Pinel-Alloul, A. Giguere and P. G. Campbell 2004 Metal-induced stress in bivalves living along a gradient of Cd contamination: relating sub-cellular metal distribution to population-level responses Heavy metal Pyganodon grandis
367 S. N. Frank, C. Singer and B. Sures 2008 Metallothionein (MT) response after chronic palladium exposure in the zebra mussel, Dreissena polymorpha Heavy metal Dreissena polymorpha
368 Y. Fang, H. Yang, T. Wang, B. Liu, H. Zhao and M. Chen 2010 Metallothionein and superoxide dismutase responses to sublethal cadmium exposure in the clam Mactra veneriformis Heavy metal Mactra veneriformis
369 G. Andreani, E. Carpene, G. Capranico and G. Isani 2011 Metallothionein cDNA cloning, metallothionein expression and heavy metals in Scapharca inaequivalvis along the Northern Adriatic coast of Italy Heavy metal Scapharca inaequivalvis
370 H. W. Khoo and K. H. Patel 1999 Metallothionein cDNA, promoter, and genomic sequences of the tropical green mussel, Perna viridis Gene expression Perna viridis
371 A. Bigot, P. Doyen, P. Vasseur and F. Rodius 2009 Metallothionein coding sequence identification and seasonal mRNA expression of detoxification genes in the bivalve Corbicula fluminea Biomarker Corbicula fluminea
372 Y. Mourgaud, E. Martinez, A. Geffard, B. Andral, J. Y. Stanisiere and J. C. Amiard 2002 Metallothionein concentration in the mussel Mytilus galloprovincialis as a biomarker of response to metal contamination: validation in the field Biomarker Mytilus galloprovincialis
373 M. J. Bebianno, A. Cravo, C. Miguel and S. Morais 2003 Metallothionein concentrations in a population of Patella aspera: variation with size Heavy metal Patella aspera
374 V. Marie, P. Gonzalez, M. Baudrimont, I. Boutet, D. Moraga, J. P. Bourdineaud and A. Boudou 2006 Metallothionein gene expression and protein levels in triploid and diploid oysters Crassostrea gigas after exposure to cadmium and zinc Heavy metal Crassostrea gigas
375 P. E. Baurand, R. Dallinger, N. Capelli and A. de Vaufleury 2016 Metallothionein gene expression in embryos of the terrestrial snail (Cantareus aspersus) exposed to cadmium and copper in the Bordeaux mixture Heavy metal Cantareus aspersus
376 R. Dallinger, B. Berger, P. Hunziker and J. H. Kagi 1997 Metallothionein in snail Cd and Cu metabolism Heavy metal Helix pomatia, Arianta arbustorum
377 R. Urena, M. Joao Bebianno, J. Del Ramo and A. Torreblanca 2010 Metallothionein in the freshwater gastropod Melanopsis dufouri chronically exposed to cadmium: a methodological approach Heavy metal Melanopsis dufouri
378 K. M. Leung and R. W. Furness 2001 Metallothionein induction and condition index of dogwhelks Nucella lapillus (L.) exposed to cadmium and hydrogen peroxide Heavy metal Nucella lapillus
379 G. Roesijadi 1994 Metallothionein induction as a measure of response to metal exposure in aquatic animals Heavy metal Crassostrea virginica
380 E. Cotou, C. Vagias, T. Rapti and V. Roussis 2001 Metallothionein levels in the bivalves Callista chione and Venus verrucosa from two Mediterranean sites Biomarker Callista chione, Venus verrucosa
381 G. Roesijadi, L. L. Brubacher, M. E. Unger and R. S. Anderson 1997 Metallothionein mRNA induction and generation of reactive oxygen species in molluscan hemocytes exposed to cadmium in vitro Heavy metal Crassostrea virginica
382 R. Dallinger 1996 Metallothionein research in terrestrial invertebrates: synopsis and perspectives Biomarker Drosophila melanogaster, Caenorhabditis elegans, Helix pomatia, Arianta arbustorum
383 V. Marie, P. Gonzalez, M. Baudrimont, J. P. Bourdineaud and A. Boudou 2006 Metallothionein response to cadmium and zinc exposures compared in two freshwater bivalves, Dreissena polymorpha and Corbicula fluminea Heavy metal Corbicula fluminea, Dreissena polymorpha
384 M. S. Diniz, H. M. Santos, P. M. Costa, I. Peres, M. H. Costa and J. L. Capelo 2007 Metallothionein responses in the Asiatic clam (Corbicula fluminea) after exposure to trivalent arsenic Heavy metal Corbicula fluminea
385 A. Serafim and M. J. Bebianno 2009 Metallothionein role in the kinetic model of copper accumulation and elimination in the clam Ruditapes decussatus Heavy metal Ruditapes decussatus
386 T. Y. Ng, P. S. Rainbow, C. Amiard-Triquet, J. C. Amiard and W. X. Wang 2007 Metallothionein turnover, cytosolic distribution and the uptake of Cd by the green mussel Perna viridis Heavy metal Perna viridis
387 F. Liu and W. X. Wang 2011 Metallothionein-like proteins turnover, Cd and Zn biokinetics in the dietary Cd-exposed scallop Chlamys nobilis Heavy metal Chlamys nobilis
388 G. Isani, G. Andreani, M. Kindt and E. Carpene 2000 Metallothioneins (MTs) in marine molluscs MT gene None
389 J. Raimundo, P. M. Costa, C. Vale, M. H. Costa and I. Moura 2010 Metallothioneins and trace elements in digestive gland, gills, kidney and gonads of Octopus vulgaris Heavy metal Octopus vulgaris
390 K. M. Leung, R. E. Dewhurst, H. Halldorsson and J. Svavarsson 2005 Metallothioneins and trace metals in the dogwhelk Nucella lapillus (L.) collected from Icelandic coasts Trace metal Nucella lapillus
391 C. Amiard-Triquet, F. Rainglet, C. Larroux, F. Regoli and H. Hummel 1998 Metallothioneins in Arctic bivalves Trace metal Macoma balthica, Mytilus edulis
392 R. Dallinger, B. Berger, C. Gruber, P. Hunziker and S. Sturzenbaum 2000 Metallothioneins in terrestrial invertebrates: structural aspects, biological significance and implications for their use as biomarkers Biomarker Helix pomatia
393 H. F. Maltez, M. Villanueva Tagle, R. Fernandez de la Campa Mdel and A. Sanz-Medel 2009 Metal-metallothioneins like proteins investigation by heteroatom-tagged proteomics in two different snails as possible sentinel organisms of metal contamination in freshwater ecosystems Metal Marisa cornuarietis, Pomacea bridgesi
394 S. Chiesa, P. Chainho, A. Almeida, E. Figueira, A. Soares and R. Freitas 2018 Metals and As content in sediments and Manila clam Ruditapes philippinarum in the Tagus estuary (Portugal): Impacts and risk for human consumption Metal Ruditapes philippinarum
395 L. F. Oliveira, M. T. Cabral, C. E. Vieira, M. H. Antoniazzi, W. E. Risso and C. B. Martinez 2016 Metals bioaccumulation and biomarkers responses in the Neotropical freshwater clam Anodontites trapesialis: Implications for monitoring coal mining areas Biomarker Anodontites trapesialis
396 S. Craig and J. Overnell 2003 Metals in squid, Loligo forbesi, adults, eggs and hatchlings. No evidence for a role for Cu- or Zn-metallothionein Heavy metal Loligo forbesi
397 T. Y. Ng and W. X. Wang 2005 Modeling of cadmium bioaccumulation in two populations of the green mussel Perna viridis Heavy metal Perna viridis
398 D. Shi and W. X. Wang 2004 Modification of trace metal accumulation in the green mussel Perna viridis by exposure to Ag, Cu, and Zn Trace metal Perna viridis
399 X. N. Verlecar, K. B. Jena and G. B. Chainy 2008 Modulation of antioxidant defences in digestive gland of Perna viridis (L.), on mercury exposures Antioxidant Perna viridis
400 S. Franzellitti, A. Viarengo, E. Dinelli and E. Fabbri 2012 Molecular and cellular effects induced by hexavalent chromium in Mediterranean mussels Heavy metal Mytilus galloprovincialis
401 A. Sarkar, D. Ray, A. N. Shrivastava and S. Sarker 2006 Molecular Biomarkers: their significance and application in marine pollution monitoring Biomarker Callionymus lyra, Limanda limanda, Serranus sp., Mullus barbatus, Dreissena polymorpha, Planaxis sulcatus, Asterias rubens
402 C. Wang, J. Sheng, Y. Hong, K. Peng, J. Wang, D. Wu, J. Shi and B. Hu 2016 Molecular characterization and expression of metallothionein from freshwater pearl mussel, Hyriopsis schlegelii Phylogenetic Hyriopsis schlegelii
403 L. Vergani, M. Grattarola, E. Grasselli, F. Dondero and A. Viarengo 2007 Molecular characterization and function analysis of MT-10 and MT-20 metallothionein isoforms from Mytilus galloprovincialis Heavy metal Mytilus galloprovincialis
404 C. Blaise, F. Gagne, J. Pellerin, P. D. Hansen and S. Trottier 2002 Molluscan shellfish biomarker study of the Quebec, Canada, Saguenay Fjord with the soft-shell clam, Mya arenaria Biomarker Mya arenaria
405 A. Calisi, M. G. Lionetto, R. Caricato, M. E. Giordano and T. Schettino 2008 Morphometric alterations in Mytilus galloprovincialis granulocytes: a new biomarker Biomarker Mytilus galloprovincialis
406 D. Ozkan, M. Dagdeviren, S. Katalay, A. Guner and N. U. Yavasoglu 2017 Multi-Biomarker Responses After Exposure to Pollution in the Mediterranean Mussels (Mytilus galloprovincialis L.) in the Aegean Coast of Turkey Biomarker Mytilus galloprovincialis
407 M. Faria, L. Carrasco, S. Diez, M. C. Riva, J. M. Bayona and C. Barata 2009 Multi-biomarker responses in the freshwater mussel Dreissena polymorpha exposed to polychlorobiphenyls and metals Biomarker Dreissena polymorpha
408 H. I. Falfushynska, L. Delahaut, O. B. Stolyar, A. Geffard and S. Biagianti-Risbourg 2009 Multi-biomarkers approach in different organs of Anodonta cygnea from the Dnister Basin (Ukraine) Biomarker Anodonta cygnea
409 J. T. Bray, L. A. Webb and F. J. Reilly, Jr. 1983 Multielement analysis of metal-binding proteins in cytosol fractions Metal Macoma balthica, Rangia cuneata
410 M. Romeo, Y. Mourgaud, A. Geffard, M. Gnassia-Barelli, J. C. Amiard and H. Budzinski 2003 Multimarker approach in transplanted mussels for evaluating water quality in Charentes, France, coast areas exposed to different anthropogenic conditions Biomarker None
411 C. Tsangaris, K. Kormas, E. Strogyloudi, I. Hatzianestis, C. Neofitou, B. Andral and F. Galgani 2010 Multiple biomarkers of pollution effects in caged mussels on the Greek coastline Biomarker None
412 A. Itziou and V. K. Dimitriadis 2012 Multiple pollution biomarker application on tissues of Eobania vermiculata during two periods characterized by augmented and reduced snail activity Biomarker Eobania vermiculata
413 P. F. La Porte 2005 Mytilus trossulus hsp70 as a biomarker for arsenic exposure in the marine environment: laboratory and real-world results Biomarker Mytilus trossulus
414 S. Zimmermann, N. Ruchter, K. Loza, M. Epple and B. Sures 2017 Nanoparticulate versus ionic silver: Behavior in the tank water, bioaccumulation, elimination and subcellular distribution in the freshwater mussel Dreissena polymorpha Heavy metal Dreissena polymorpha
415 V. Talbot and R. J. Magee 1978 Naturally-occurring heavy metal binding protein in invertebrates Heavy metal Mytilus edulis
416 M. Hockner, R. Dallinger and S. R. Sturzenbaum 2011 Nematode and snail metallothioneins Biomarker Caenorhabditis elegans, Helix pomatia, Cantareus aspersus
417 A. Romero-Ruiz, J. Alhama, J. Blasco, J. L. Gomez-Ariza and J. Lopez-Barea 2008 New metallothionein assay in Scrobicularia plana: heating effect and correlation with other biomarkers Biomarker Scrobicularia plana
418 H. Stone and J. Overnell 1985 Non-metallothionein cadmium binding proteins Heavy metal Pseudomonas putida, Synechococcus sp. , Schizosaccharomyces pombe, Saccharomyces
cerevisiae, Neurospora crassa
419 E. Del Castillo and W. E. Robinson 2008 Nuclear and cytosolic distribution of metallothionein in the blue mussel Mytilus edulis L MT gene Mytilus edulis
420 F. Palais, O. Dedourge-Geffard, A. Beaudon, S. Pain-Devin, J. Trapp, O. Geffard, P. Noury, C. Gourlay-France, E. Uher, C. Mouneyrac, S. Biagianti-Risbourg and A. Geffard 2012 One-year monitoring of core biomarker and digestive enzyme responses in transplanted zebra mussels (Dreissena polymorpha) Biomarker Dreissena polymorpha
421 A. Nardi, M. Benedetti, D. Fattorini and F. Regoli 2018 Oxidative and interactive challenge of cadmium and ocean acidification on the smooth scallop Flexopecten glaber Heavy metal Flexopecten glaber
422 G. G. Kournoutou, P. C. Giannopoulou, E. Sazakli, M. Leotsinidis and D. L. Kalpaxis 2017 Oxidative damage of 18S and 5S ribosomal RNA in digestive gland of mussels exposed to trace metals Trace metal Mytilus galloprovincialis
423 M. Benedetti, I. Lanzoni, A. Nardi, G. d'Errico, M. Di Carlo, D. Fattorini, M. Nigro and F. Regoli 2016 Oxidative responsiveness to multiple stressors in the key Antarctic species, Adamussium colbecki: Interactions between temperature, acidification and cadmium exposure Heavy metal Adamussium colbecki
424 A. Romero-Ruiz, O. Amezcua, M. J. Rodriguez-Ortega, J. L. Munoz, J. Alhama, A. Rodriguez-Ariza, J. L. Gomez-Ariza and J. Lopez-Barea 2003 Oxidative stress biomarkers in bivalves transplanted to the Guadalquivir estuary after Aznalcollar spill Biomarker Scrobicularia plana
425 K. Y. Abdel-Halim, A. M. Abo El-Saad, M. M. Talha, A. A. Hussein and N. M. Bakry 2013 Oxidative stress on land snail Helix aspersa as a sentinel organism for ecotoxicological effects of urban pollution with heavy metals Heavy metal Helix aspersa
426 R. S. Anderson, K. M. Patel and G. Roesijadi 1999 Oyster metallothionein as an oxyradical scavenger: implications for hemocyte defense responses Heavy metal Crassostrea virginica, rabbit
427 M. J. Jenny, S. L. Payton, D. A. Baltzegar and J. D. Lozier 2016 Phylogenetic Analysis of Molluscan Metallothioneins: Evolutionary Insight from Crassostrea virginica Phylogenetic Crassostrea virginica
428 R. W. Olafson, R. G. Sim and A. Kearns 1979 Physiological and chemical characterization of invertebrate metallothionein-like proteins MT gene Scyllus serratus, Cancer magister, Acetes sibogae, Cryptochiton stelleri
429 M. Hockner, K. Stefanon, A. de Vaufleury, F. Monteiro, S. Perez-Rafael, O. Palacios, M. Capdevila, S. Atrian and R. Dallinger 2011 Physiological relevance and contribution to metal balance of specific and non-specific Metallothionein isoforms in the garden snail, Cantareus aspersus Heavy metal Cantareus aspersus
430 V. Pedrini-Martha, M. Niederwanger, R. Kopp, R. Schnegg and R. Dallinger 2016 Physiological, Diurnal and Stress-Related Variability of Cadmium-Metallothionein Gene Expression in Land Snails Heavy metal Helix pomatia
431 C. Barmo, C. Ciacci, R. Fabbri, S. Olivieri, N. Bianchi, G. Gallo and L. Canesi 2011 Pleiotropic effects of hexavalent chromium (CrVI) in Mytilus galloprovincialis digestive gland Heavy metal Mytilus galloprovincialis
432 M. Sole, J. Kopecka-Pilarczyk and J. Blasco 2009 Pollution biomarkers in two estuarine invertebrates, Nereis diversicolor and Scrobicularia plana, from a Marsh ecosystem in SW Spain Biomarker Nereis diversicolor, Scrobicularia plana
433 A. Tanguy, I. Boutet, F. Bonhomme, P. Boudry and D. Moraga 2002 Polymorphism of metallothionein genes in the Pacific oyster Crassostrea gigas as a biomarker of response to metal exposure Biomarker Crassostrea gigas
434 O. F. Tankoua, P. E. Buffet, J. C. Amiard, C. Amiard-Triquet, C. Mouneyrac and B. Berthet 2011 Potential influence of confounding factors (size, salinity) on biomarkers in the sentinel species Scrobicularia plana used in programmes monitoring estuarine quality Biomarker Scrobicularia plana
435 L. Soazig and L. Marc 2003 Potential use of the levels of the mRNA of a specific metallothionein isoform (MT-20) in mussel (Mytilus edulis) as a biomarker of cadmium contamination Biomarker Mytilus edulis
436 S. Santiago-Rivas, A. Moreda-Pineiro, P. Bermejo-Barrera, J. Moreda-Pineiro, E. Alonso-Rodriguez, S. Muniategui-Lorenzo, P. Lopez-Mahia and D. Prada-Rodriguez 2007 Pressurized liquid extraction-assisted mussel cytosol preparation for the determination of metals bound to metallothionein-like proteins Metal Mytilus galloprovincialis
437 B. Berger, R. Dallinger, P. Gehrig and P. E. Hunziker 1997 Primary structure of a copper-binding metallothionein from mantle tissue of the terrestrial gastropod Helix pomatia L Heavy metal Helix pomatia
438 M. E. Unger, T. T. Chen, C. M. Murphy, M. M. Vestling, C. Fenselau and G. Roesijadi 1991 Primary structure of molluscan metallothioneins deduced from PCR-amplified cDNA and mass spectrometry of purified proteins Heavy metal Crassostrea virginica
439 S. N. Pedersen, K. L. Pedersen, P. Hojrup, M. H. Depledge and J. Knudsen 1996 Primary structures of decapod crustacean metallothioneins with special emphasis on freshwater and semi-terrestrial species Heavy metal Potamon potamios, Astacus astacus
440 A. Marques, D. Pilo, O. Araujo, F. Pereira, S. Guilherme, S. Carvalho, M. A. Santos, M. Pacheco and P. Pereira 2016 Propensity to metal accumulation and oxidative stress responses of two benthic species (Cerastoderma edule and Nephtys hombergii): are tolerance processes limiting their responsiveness? Metal Cerastoderma edule, Nephtys hombergii
441 L. Xu, X. Peng, D. Yu, C. Ji, J. Zhao and H. Wu 2016 Proteomic responses reveal the differential effects induced by cadmium in mussels Mytilus galloprovincialis at early life stages Heavy metal Mytilus galloprovincialis
442 S. K. Ryu, J. S. Park and I. S. Lee 2003 Purification and characterization of a copper-binding protein from Asian periwinkle Littorina brevicula Heavy metal Littorina brevicula
443 J. S. Park, S. Chung, I. S. Park, Y. Kim, C. Koh and I. S. Lee 2002 Purification and characterization of metallothionein-like cadmium binding protein from Asian periwinkle Littorina brevicula Heavy metal Littorina brevicula
444 B. A. Fowler, D. W. Engel and M. Brouwer 1986 Purification and characterization studies of cadmium-binding proteins from the American oyster, Crassostrea virginica Heavy metal Crassostrea virginica
445 Y. Dohi, K. Ohba and Y. Yoneyama 1983 Purification and molecular properties of two cadmium-binding glycoproteins from the hepatopancreas of a whelk, Buccinum tenuissimum Heavy metal Buccinum tenuissimum
446 R. Dallinger, B. Berger, P. E. Hunziker, N. Birchler, C. R. Hauer and J. H. Kagi 1993 Purification and primary structure of snail metallothionein. Similarity of the N-terminal sequence with histones H4 and H2A Heavy metal Helix pomatia
447 G. Roesijadi, S. Kielland and P. Klerks 1989 Purification and properties of novel molluscan metallothioneins Heavy metal Crassostrea virginica
448 I. El Ghazi, S. Menge, J. Miersch, A. Chafik, A. Benhra, M. K. Elamrani and G. J. Krauss 2003 Quantification of metallothionein-like proteins in the mussel Mytilus galloprovincialis using RP-HPLC fluorescence detection Heavy metal Mytilus galloprovincialis
449 F. Dondero, L. Piacentini, M. Banni, M. Rebelo, B. Burlando and A. Viarengo 2005 Quantitative PCR analysis of two molluscan metallothionein genes unveils differential expression and regulation Heavy metal Mytilus galloprovincialis
450 A. Buico, C. Cassino, F. Dondero, L. Vergani and D. Osella 2008 Radical scavenging abilities of fish MT-A and mussel MT-10 metallothionein isoforms: An ESR study Heavy metal Mytilus galloprovincialis, Oncorhyncus mykiss
451 A. Torreggiani, J. Domenech, S. Atrian, M. Capdevila and A. Tinti 2008 Raman study of in vivo synthesized Zn(II)-metallothionein complexes: structural insight into metal clusters and protein folding Heavy metal None
452 K. Lilja, A. Prevodnik, J. Gardestrom, T. Elfwing, M. Tedengren and T. Bollner 2008 Regional differences in mRNA responses in blue mussels within the Baltic proper Heavy metal Mytilus sp.
453 M. J. Jenny, G. W. Warr, A. H. Ringwood, D. A. Baltzegar and R. W. Chapman 2006 Regulation of metallothionein genes in the American oyster (Crassostrea virginica): ontogeny and differential expression in response to different stressors Heavy metal Crassostrea virginica
454 A. Hamza-Chaffai, J. C. Amiard and R. P. Cosson 1999 Relationship between metallothioneins and metals in a natural population of the clam Ruditapes decussatus from Sfax coast: a non-linear model using Box-Cox transformation Metal Ruditapes decussatus
455 F. Geret, A. Serafim, L. Barreira and M. J. Bebianno 2002 Response of antioxidant systems to copper in the gills of the clam Ruditapes decussatus Antioxidant Ruditapes decussatus
456 E. David, A. Tanguy, K. Pichavant and D. Moraga 2005 Response of the Pacific oyster Crassostrea gigas to hypoxia exposure under experimental conditions Genetic marker Crassostrea gigas
457 Y. Gueguen, S. Denis, S. Adrien, M. Kevin, G. Pierre, B. Solene, N. Marine, B. Patrick, H. Herehia, P. Serge and L. M. Gilles 2017 Response of the pearl oyster Pinctada margaritifera to cadmium and chromium: Identification of molecular biomarkers Biomarker Pinctada margaritifera
458 X. Huang, F. Guo, C. Ke and W. X. Wang 2010 Responses of abalone Haliotis diversicolor to sublethal exposure of waterborne and dietary silver and cadmium Heavy metal Haliotis diversicolor
459 E. David, A. Tanguy, R. Riso, L. Quiniou, J. Laroche and D. Moraga 2012 Responses of Pacific oyster Crassostrea gigas populations to abiotic stress in environmentally contrasted estuaries along the Atlantic coast of France Genetic marker Crassostrea gigas
460 S. Masson, Y. Couillard, P. G. Campbell, C. Olsen, B. Pinel-Alloul and O. Perceval 2010 Responses of two sentinel species (Hexagenia limbata--mayfly; Pyganodon grandis--bivalve) along spatial cadmium gradients in lakes and rivers in northwestern Quebec Heavy metal Hexagenia limbata, Pyganodon grandis
461 Z. Wang, Y. Shao, C. Li, W. Zhang, X. Duan, X. Zhao, Q. Qiu and C. Jin 2016 RNA-seq analysis revealed ROS-mediated related genes involved in cadmium detoxification in the razor clam Sinonovacula constricta Heavy metal Sinonovacula constricta
462 S. Dailianis and M. Kaloyianni 2007 Role of cAMP in tissues of mussel Mytilus galloprovincialis as a potent biomarker of cadmium in marine environments Biomarker Mytilus galloprovincialis
463 A. Viarengo, B. Burlando, M. Cavaletto, B. Marchi, E. Ponzano and J. Blasco 1999 Role of metallothionein against oxidative stress in the mussel Mytilus galloprovincialis Antioxidant Mytilus galloprovincialis
464 E. Strady, G. Blanc, M. Baudrimont, J. Schafer, S. Robert and V. Lafon 2011 Roles of regional hydrodynamic and trophic contamination in cadmium bioaccumulation by Pacific oysters in the Marennes-Oleron Bay (France) Heavy metal Oysters
465 E. Figueira, P. Cardoso and R. Freitas 2012 Ruditapes decussatus and Ruditapes philippinarum exposed to cadmium: toxicological effects and bioaccumulation patterns Heavy metal Ruditapes decussatus, Ruditapes philippinarum
466 A. Acs, A. Vehovszky, J. Gyori and A. Farkas 2016 Seasonal and size-related variation of subcellular biomarkers in quagga mussels (Dreissena bugensis) inhabiting sites affected by moderate contamination with complex mixtures of pollutants Biomarker Dreissena bugensis
467 E. Farcy, C. Voiseux, J. M. Lebel and B. Fievet 2007 Seasonal changes in mRNA encoding for cell stress markers in the oyster Crassostrea gigas exposed to radioactive discharges in their natural environment Biomarker Crassostrea gigas
468 R. Serra, G. Isani, G. Tramontano and E. Carpene 1999 Seasonal dependence of cadmium accumulation and Cd-binding proteins in Mytilus galloprovincialis exposed to cadmium Heavy metal Mytilus galloprovincialis
469 J. F. P. Oaten, M. D. Hudson, A. C. Jensen and I. D. Williams 2017 Seasonal effects to metallothionein responses to metal exposure in a naturalised population of Ruditapes philippinarum in a semi-enclosed estuarine environment Biomarker Ruditapes philippinarum
470 S. Leinio and K. K. Lehtonen 2005 Seasonal variability in biomarkers in the bivalves Mytilus edulis and Macoma balthica from the northern Baltic Sea Biomarker Mytilus edulis, Macoma balthica
471 T. Balbi, R. Fabbri, M. Montagna, G. Camisassi and L. Canesi 2017 Seasonal variability of different biomarkers in mussels (Mytilus galloprovincialis) farmed at different sites of the Gulf of La Spezia, Ligurian sea, Italy Biomarker Mytilus galloprovincialis
472 R. Bocchetti and F. Regoli 2006 Seasonal variability of oxidative biomarkers, lysosomal parameters, metallothioneins and peroxisomal enzymes in the Mediterranean mussel Mytilus galloprovincialis from Adriatic Sea Biomarker Mytilus galloprovincialis
473 S. Jarque, E. Prats, A. Olivares, M. Casado, M. Ramon and B. Pina 2014 Seasonal variations of gene expression biomarkers in Mytilus galloprovincialis cultured populations: temperature, oxidative stress and reproductive cycle as major modulators Biomarker Mytilus galloprovincialis
474 A. L. Meistertzheim, M. Lejart, N. Le Goic and M. T. Thebault 2009 Sex-, gametogenesis, and tidal height-related differences in levels of HSP70 and metallothioneins in the Pacific oyster Crassostrea gigas Biomarker Crassostrea gigas
475 O. Palacios, A. Pagani, S. Perez-Rafael, M. Egg, M. Hockner, A. Brandstatter, M. Capdevila, S. Atrian and R. Dallinger 2011 Shaping mechanisms of metal specificity in a family of metazoan metallothioneins: evolutionary differentiation of mollusc metallothioneins Heavy metal Helix pomatia
476 A. V. Ivanina, E. Beniash, M. Etzkorn, T. B. Meyers, A. H. Ringwood and I. M. Sokolova 2013 Short-term acute hypercapnia affects cellular responses to trace metals in the hard clams Mercenaria mercenaria Trace metal Mercenaria mercenaria
477 A. Long, C. Li, S. Chen, W. Yan, A. Dang, Y. Cheng and D. Lu 2010 Short-term metal accumulation and MTLP induction in the digestive glands of Perna virdis exposed to Zn and Cd Heavy metal Perna virdis
478 I. Paul-Pont, P. Gonzalez, M. Baudrimont, H. Nili and X. de Montaudouin 2010 Short-term metallothionein inductions in the edible cockle Cerastoderma edule after cadmium or mercury exposure: discrepancy between mRNA and protein responses Heavy metal Cerastoderma edule
479 I. Lavilla, M. Costas, S. Gil, S. Corderi, G. Sanchez and C. Bendicho 2012 Simplified and miniaturized procedure based on ultrasound-assisted cytosol preparation for the determination of Cd and Cu bound to metallothioneins in mussel tissue by ICP-MS Heavy metal None
480 E. Garcia-Luque, T. A. DelValls, C. Casado-Martinez, J. M. Forja and A. Gomez-Parra 2004 Simulating a heavy metal spill under estuarine conditions: effects on the clam Scrobicularia plana Heavy metal Scrobicularia plana
481 J. F. Pan, P. E. Buffet, L. Poirier, C. Amiard-Triquet, D. Gilliland, Y. Joubert, P. Pilet, M. Guibbolini, C. Risso de Faverney, M. Romeo, E. Valsami-Jones and C. Mouneyrac 2012 Size dependent bioaccumulation and ecotoxicity of gold nanoparticles in an endobenthic invertebrate: the Tellinid clam Scrobicularia plana Biomarker Scrobicularia plana
482 V. Leignel, Y. Hardivillier and M. Laulier 2005 Small metallothionein MT-10 genes in coastal and hydrothermal mussels MT gene Mytilus edulis, Bathymodiolus thermophilus
483 A. Bigot, P. Vasseur and F. Rodius 2010 SOD and CAT cDNA cloning, and expression pattern of detoxification genes in the freshwater bivalve Unio tumidus transplanted into the Moselle river Biomarker Unio tumidus
484 V. Bragigand and B. Berthet 2003 Some methodological aspects of metallothionein evaluation MT gene Crassostrea gigas, Hediste/Nereis diversicolor
485 A. Cravo, B. Lopes, A. Serafim, R. Company, L. Barreira, T. Gomes and M. J. Bebianno 2013 Spatial and seasonal biomarker responses in the clam Ruditapes decussatus Biomarker Ruditapes decussatus
486 I. Werner and D. E. Hinton 2000 Spatial profiles of hsp70 proteins in Asian clam (Potamocorbula amurensis) in northern San Francisco Bay may be linked to natural rather than anthropogenic stressors Heavy metal Potamocorbula amurensis
487 X. J. Yu, K. Pan, F. Liu, Y. Yan and W. X. Wang 2013 Spatial variation and subcellular binding of metals in oysters from a large estuary in China Metal Crassostrea hongkongensis
488 C. N. Ferrarello, M. R. Fernandez de la Campa, J. F. Carrasco and A. Sanz-Medel 2000 Speciation of metallothionein-like proteins of the mussel Mytilus edulis at basal levels by chromatographic separations coupled to quadrupole and double-focusing magnetic sector ICPMS Heavy metal Mytilus edulis
489 R. Dallinger, Y. Wang, B. Berger, E. A. Mackay and J. H. Kagi 2001 Spectroscopic characterization of metallothionein from the terrestrial snail, Helix pomatia Heavy metal Helix pomatia
490 A. Giguere, Y. Couillard, P. G. Campbell, O. Perceval, L. Hare, B. Pinel-Alloul and J. Pellerin 2003 Steady-state distribution of metals among metallothionein and other cytosolic ligands and links to cytotoxicity in bivalves living along a polymetallic gradient Metal Pyganodon grandis
491 D. M. Pampanin, I. Marangon, E. Volpato, G. Campesan and C. Nasci 2005 Stress biomarkers and alkali-labile phosphate level in mussels (Mytilus galloprovincialis) collected in the urban area of Venice (Venice Lagoon, Italy) Biomarker Mytilus galloprovincialis
492 D. Moraga, A. L. Meistertzheim, S. Tanguy-Royer, I. Boutet, A. Tanguy and A. Donval 2005 Stress response in Cu2+ and Cd2+ exposed oysters (Crassostrea gigas): an immunohistochemical approach Heavy metal Crassostrea gigas
493 T. Sone, Y. Haraguchi, A. Kuwahara, T. Ose, M. Takano, A. Abe, M. Tanaka, I. Tanaka and K. Asano 2015 Structural characterization reveals the keratinolytic activity of an arthrobacter nicotinovorans protease Heavy metal Arthrobacter nicotinovorans, Patiopecten yessoensis,  Nesterenkonia sp.
494 G. Roesijadi, M. M. Vestling, C. M. Murphy, P. L. Klerks and C. C. Fenselau 1991 Structure and time-dependent behavior of acetylated and non-acetylated forms of a molluscan metallothionein Heavy metal Crassostrea virginica
495 M. S. Cheung, E. M. Fok, T. Y. Ng, Y. F. Yen and W. X. Wang 2006 Subcellular cadmium distribution, accumulation, and toxicity in a predatory gastropod, thais Clavigera, fed different prey Heavy metal Thais clavigera
496 M. Soto, B. Zaldibar, I. Cancio, M. G. Taylor, M. Turner, A. J. Morgan and I. Marigomez 2002 Subcellular distribution of cadmium and its cellular ligands in mussel digestive gland cells as revealed by combined autometallography and X-ray microprobe analysis Heavy metal Mytilus galloprovincialis
497 T. L. Rocha, T. Gomes, E. G. Durigon and M. J. Bebianno 2016 Subcellular partitioning kinetics, metallothionein response and oxidative damage in the marine mussel Mytilus galloprovincialis exposed to cadmium-based quantum dots Heavy metal Mytilus galloprovincialis
498 E. Bonneris, O. Perceval, S. Masson, L. Hare and P. G. Campbell 2005 Sub-cellular partitioning of Cd, Cu and Zn in tissues of indigenous unionid bivalves living along a metal exposure gradient and links to metal-induced effects Heavy metal Pyganodon grandis
499 E. Bonneris, A. Giguere, O. Perceval, T. Buronfosse, S. Masson, L. Hare and P. G. Campbell 2005 Sub-cellular partitioning of metals (Cd, Cu, Zn) in the gills of a freshwater bivalve, Pyganodon grandis: role of calcium concretions in metal sequestration Heavy metal Pyganodon grandis
500 Z. Wang, C. Feng, C. Ye, Y. Wang, C. Yan, R. Li, Y. Yan and Q. Chi 2016 Subcellular partitioning profiles and metallothionein levels in indigenous clams Moerella iridescens from a metal-impacted coastal bay Heavy metal Moerella iridescens
501 R. Company, A. Serafim, R. P. Cosson, A. Fiala-Medioni, L. Camus, R. Serrao-Santos and M. Joao Bebianno 2010 Sub-lethal effects of cadmium on the antioxidant defence system of the hydrothermal vent mussel Bathymodiolus azoricus Heavy metal Bathymodiolus azoricus
502 D. Benito, M. Niederwanger, U. Izagirre, R. Dallinger and M. Soto 2017 Successive Onset of Molecular, Cellular and Tissue-Specific Responses in Midgut Gland of Littorina littorea Exposed to Sub-Lethal Cadmium Concentrations Heavy metal Littorina littorea
503 K. M. Leung and R. W. Furness 2001 Survival, growth, metallothionein and glycogen levels of Nucella lapillus (L.) exposed to subchronic cadmium stress: the influence of nutritional state and prey type Heavy metal Nucella lapillus
504 D. M. Pampanin, L. Camus, A. Gomiero, I. Marangon, E. Volpato and C. Nasci 2005 Susceptibility to oxidative stress of mussels (Mytilus galloprovincialis) in the Venice Lagoon (Italy) Antioxidant Mytilus galloprovincialis
505 E. J. Won, K. T. Kim, J. Y. Choi, E. S. Kim and K. Ra 2016 Target organs of the Manila clam Ruditapes philippinarum for studying metal accumulation and biomarkers in pollution monitoring: laboratory and in-situ transplantation experiments Biomarker Ruditapes philippinarum
506 C. K. Yap, A. Noorhaidah, A. Azlan, A. A. Nor Azwady, A. Ismail, A. R. Ismail, S. S. Siraj and S. G. Tan 2009 Telescopium telescopium as potential biomonitors of Cu, Zn, and Pb for the tropical intertidal area Heavy metal Telescopium telescopium
507 K. K. Lehtonen, D. Schiedek, A. Kohler, T. Lang, P. J. Vuorinen, L. Forlin, J. Barsiene, J. Pempkowiak and J. Gercken 2006 The BEEP project in the Baltic Sea: overview of results and outline for a regional biological effects monitoring strategy Biomarker Mytilus spp., Platichthys flesus, Zoarces viviparus
508 V. Contardo-Jara, S. Pflugmacher, G. Nutzmann, W. Kloas and C. Wiegand 2010 The beta-receptor blocker metoprolol alters detoxification processes in the non-target organism Dreissena polymorpha Detoxification Dreissena polymorpha
509 G. Digilio, C. Bracco, L. Vergani, M. Botta, D. Osella and A. Viarengo 2009 The cadmium binding domains in the metallothionein isoform Cd(7)-MT10 from Mytilus galloprovincialis revealed by NMR spectroscopy Heavy metal Mytilus galloprovincialis
510 O. B. Stolyar, R. L. Myhayliv and O. V. Mischuk 2005 The concentration-specific response of metallothioneins in copper-loading freshwater bivalve Anodonta cygnea Heavy metal Anodonta cygnea
511 M. Machreki-Ajmi, I. Ketata, R. Ladhar-Chaabouni and A. Hamza-Chaffai 2008 The effect of in situ cadmium contamination on some biomarkers in Cerastoderma glaucum Biomarker Cerastoderma glaucum
512 W. Schmidt, T. O'Shea and B. Quinn 2012 The effect of shore location on biomarker expression in wild Mytilus spp. and its comparison with long line cultivated mussels Biomarker Mytilus spp., Mytilus edulis, Mytilus galloprovincialis
513 A. H. Ringwood, M. McCarthy, T. C. Bates and D. L. Carroll 2010 The effects of silver nanoparticles on oyster embryos Heavy metal Crassostrea virginica
514 H. Falfushynska, L. Gnatyshyna, I. Yurchak, I. Sokolova and O. Stoliar 2015 The effects of zinc nanooxide on cellular stress responses of the freshwater mussels Unio tumidus are modulated by elevated temperature and organic pollutants Heavy metal Unio tumidus
515 F. Gagne, P. Turcotte, J. Auclair and C. Gagnon 2013 The effects of zinc oxide nanoparticles on the metallome in freshwater mussels Heavy metal Elliptio complanata
516 I. Martins, R. Bettencourt, A. Colaco, P. M. Sarradin, R. S. Santos and R. Cosson 2011 The influence of nutritional conditions on metal uptake by the mixotrophic dual symbiosis harboring vent mussel Bathymodiolus azoricus Metal Bathymodiolus azoricus
517 Z. Dragun, B. Raspor, M. Erk, D. Ivankovic and J. Pavicic 2006 The influence of the biometric parameters on metallothionein and metal level in the heat-treated cytosol of the whole soft tissue of transplanted mussels Biomarker Mytilus galloprovincialis
518 D. W. Engel 1983 The intracellular partitioning of trace metals in marine shellfish Trace metal Crassostrea virginica, Callincetes sapidus
519 H. Mao, D. H. Wang and W. X. Yang 2012 The involvement of metallothionein in the development of aquatic invertebrate Biomarker None
520 M. Baudrimont, S. Andres, G. Durrieu and A. Boudou 2003 The key role of metallothioneins in the bivalve Corbicula fluminea during the depuration phase, after in situ exposure to Cd and Zn Heavy metal Corbicula fluminea
521 P. B. Lobel and J. F. Payne 1987 The mercury-203 method for evaluating metallothioneins: interference by copper, mercury, oxygen, silver and selenium Heavy metal Mytilus edulis
522 S. Perez-Rafael, A. Mezger, B. Lieb, R. Dallinger, M. Capdevila, O. Palacios and S. Atrian 2012 The metal binding abilities of Megathura crenulata metallothionein (McMT) in the frame of gastropoda MTs Heavy metal Megathura crenulata
523 R. Orihuela, J. Domenech, R. Bofill, C. You, E. A. Mackay, J. H. Kagi, M. Capdevila and S. Atrian 2008 The metal-binding features of the recombinant mussel Mytilus edulis MT-10-IV metallothionein Heavy metal Mytilus edulis
524 S. Aceto, G. Formisano, F. Carella, G. De Vico and L. Gaudio 2011 The metallothionein genes of Mytilus galloprovincialis: genomic organization, tissue expression and evolution Biomarker Mytilus galloprovincialis
525 T. C. Siewicki, J. S. Sydlowski and E. S. Webb 1983 The nature of cadmium binding in commercial eastern oysters (Crassostrea virginica) Heavy metal Crassostrea virginica
526 S. G. George and B. J. Pirie 1979 The occurrence of cadmium in sub-cellular particles in the kidney of the marine mussel, Mytilus edulis, exposed to cadmium. The use of electron microprobe analysis Heavy metal Mytilus edulis
527 V. Pedrini-Martha, R. Schnegg, P. E. Baurand, A. deVaufleury and R. Dallinger 2017 The physiological role and toxicological significance of the non-metal-selective cadmium/copper-metallothionein isoform differ between embryonic and adult helicid snails Heavy metal Helix pomatia
528 C. Yang, L. Wang, Q. Jiang, J. Wang, F. Yue, H. Zhang, Z. Sun and L. Song 2013 The polymorphism in the promoter region of metallothionein 1 is associated with heat tolerance of scallop Argopecten irradians Gene expression Argopecten irradians
529 A. Hamza-Chaffai, J. C. Amiard, J. Pellerin, L. Joux and B. Berthet 2000 The potential use of metallothionein in the clam Ruditapes decussatus as a biomarker of in situ metal exposure Biomarker Ruditapes decussatus
530 L. Chen, H. Wu, J. Zhao, W. Zhang, L. Zhang, S. Sun, D. Yang, B. Cheng and Q. Wang 2018 The role of GST omega in metabolism and detoxification of arsenic in clam Ruditapes philippinarum Heavy metal Ruditapes philippinarum
531 K. Pan and W. X. Wang 2008 The subcellular fate of cadmium and zinc in the scallop Chlamys nobilis during waterborne and dietary metal exposure Heavy metal Chlamys nobilis
532 X. Liu and W. X. Wang 2016 Time changes in biomarker responses in two species of oyster transplanted into a metal contaminated estuary Biomarker Crassostrea hongkongensis, Crassostrea angulata
533 I. Zorita, E. Bilbao, A. Schad, I. Cancio, M. Soto and M. P. Cajaraville 2007 Tissue- and cell-specific expression of metallothionein genes in cadmium- and copper-exposed mussels analyzed by in situ hybridization and RT-PCR Heavy metal Mytilus galloprovincialis
534 M. M. Desouky 2006 Tissue distribution and subcellular localization of trace metals in the pond snail Lymnaea stagnalis with special reference to the role of lysosomal granules in metal sequestration Trace metal Lymnaea stagnalis
535 Y. Fang, H. Yang and B. Liu 2012 Tissue-specific response of metallothionein and superoxide dismutase in the clam Mactra veneriformis under sublethal mercury exposure Heavy metal Mactra veneriformis
536 J. Kalman, E. Bonnail-Miguel, B. D. Smith, N. R. Bury and P. S. Rainbow 2015 Toxicity and the fractional distribution of trace metals accumulated from contaminated sediments by the clam Scrobicularia plana exposed in the laboratory and the field Trace metal Scrobicularia plana
537 P. M. Costa, H. M. Santos, I. Peres, M. H. Costa, S. Alves, J. L. Capelo-Martinez and M. S. Diniz 2009 Toxicokinetics of waterborne trivalent arsenic in the freshwater bivalve Corbicula fluminea Heavy metal Corbicula fluminea
538 H. M. Santos, M. S. Diniz, P. M. Costa, I. Peres, M. H. Costa, S. Alves and J. L. Capelo 2007 Toxicological effects and bioaccumulation in the freshwater clam (Corbicula fluminea) following exposure to trivalent arsenic Heavy metal Corbicula fluminea
539 F. Gagne, C. Andre, P. Cejka, C. Gagnon and C. Blaise 2007 Toxicological effects of primary-treated urban wastewaters, before and after ozone treatment, on freshwater mussels (Elliptio complanata) Biomarker Elliptio complanata
540 Q. Zhou, Y. Zhang, H. F. Peng, C. H. Ke and H. Q. Huang 2014 Toxicological responses of the hard clam Meretrix meretrix exposed to excess dissolved iron or challenged by Vibrio parahaemolyticus Toxicity Meretrix meretrix, Vibrio parahaemolyticus
541 C. Le Pabic, C. Caplat, J. P. Lehodey, T. Milinkovitch, N. Koueta, R. P. Cosson and P. Bustamante 2015 Trace metal concentrations in post-hatching cuttlefish Sepia officinalis and consequences of dissolved zinc exposure Trace metal Sepia officinalis
542 S. Girotti, L. Bolelli, F. Fini, M. Monari, G. Andreani, G. Isani and E. Carpene 2006 Trace metals in arcid clam Scapharca inaequivalvis: effects of molluscan extracts on bioluminescent bacteria Trace metal Scapharca inaequivalvis
543 E. Strady, J. Schafer, M. Baudrimont and G. Blanc 2011 Tracing cadmium contamination kinetics and pathways in oysters (Crassostrea gigas) by multiple stable Cd isotope spike experiments Heavy metal Crassostrea gigas
544 M. Banni, A. Hajer, S. Sforzini, C. Oliveri, H. Boussetta and A. Viarengo 2014 Transcriptional expression levels and biochemical markers of oxidative stress in Mytilus galloprovincialis exposed to nickel and heat stress Biomarker Mytilus galloprovincialis
545 E. Farcy, C. Voiseux, J. M. Lebel and B. Fievet 2009 Transcriptional expression levels of cell stress marker genes in the Pacific oyster Crassostrea gigas exposed to acute thermal stress Biomarker Crassostrea gigas
546 Y. Fang, H. Yang, B. Liu and L. Zhang 2013 Transcriptional response of lysozyme, metallothionein, and superoxide dismutase to combined exposure to heavy metals and bacteria in Mactra veneriformis Heavy metal Mactra veneriformis
547 A. Navarro, M. Faria, C. Barata and B. Pina 2011 Transcriptional response of stress genes to metal exposure in zebra mussel larvae and adults Metal Dreissena polymorpha
548 S. Karray, E. Tastard, B. Moreau, L. Delahaut, A. Geffard, E. Guillon, F. Denis, A. Hamza-Chaffai, B. Chenais and J. Marchand 2015 Transcriptional response of stress-regulated genes to industrial effluent exposure in the cockle Cerastoderma glaucum Gene expression Cerastoderma glaucum
549 S. Y. Lee and Y. K. Nam 2016 Transcriptional responses of metallothionein gene to different stress factors in Pacific abalone (Haliotis discus hannai) Biomarker Haliotis discus hannai
550 H. Chalghmi, J. P. Bourdineaud, Z. Haouas, P. Y. Gourves, I. Zrafi and D. Saidane-Mosbahi 2016 Transcriptomic, Biochemical, and Histopathological Responses of the Clam Ruditapes decussatus from a Metal-Contaminated Tunis Lagoon Metal Ruditapes decussatus
551 M. S. Cheung, L. Zhang and W. X. Wang 2007 Transfer and efflux of cadmium and silver in marine snails and fish fed pre-exposed mussel prey Heavy metal Thais clavigera, Terapon jarbua
552 S. Pytharopoulou, K. Grintzalis, E. Sazakli, M. Leotsinidis, C. D. Georgiou and D. L. Kalpaxis 2011 Translational responses and oxidative stress of mussels experimentally exposed to Hg, Cu and Cd: one pattern does not fit at all Heavy metal Mytilus galloprovincialis
553 S. Pytharopoulou, E. Sazakli, K. Grintzalis, C. D. Georgiou, M. Leotsinidis and D. L. Kalpaxis 2008 Translational responses of Mytilus galloprovincialis to environmental pollution: integrating the responses to oxidative stress and other biomarker responses into a general stress index Biomarker Mytilus galloprovincialis
554 M. J. Bebianno and W. J. Langston 1993 Turnover rate of metallothionein and cadmium in Mytilus edulis Heavy metal Mytilus edulis
555 D. Shi and W. X. Wang 2004 Understanding the differences in Cd and Zn bioaccumulation and subcellular storage among different populations of marine clams Heavy metal Mactra veneriformis, Ruditapes philippinarum
556 Q. Yin and W. X. Wang 2018 Uniquely high turnover of nickel in contaminated oysters Crassostrea hongkongensis: Biokinetics and subcellular distribution Heavy metal Crassostrea hongkongensis
557 H. Attig, A. Dagnino, A. Negri, J. Jebali, H. Boussetta, A. Viarengo, F. Dondero and M. Banni 2010 Uptake and biochemical responses of mussels Mytilus galloprovincialis exposed to sublethal nickel concentrations Heavy metal Mytilus galloprovincialis
558 G. Blackmore and W. X. Wang 2002 Uptake and efflux of Cd and Zn by the green mussel Perna viridis after metal preexposure Heavy metal Perna viridis
559 D. Shi and W. X. Wang 2005 Uptake of aqueous and dietary metals by mussel Perna viridis with different Cd exposure histories Heavy metal Perna viridis
560 B. El Haimeur, M. Bouhallaoui, M. Zbiry, N. Elkhiati, S. Talba, S. Sforzini, A. Viarengo and A. Benhra 2017 Use of biomarkers to evaluate the effects of environmental stressors on Mytilus galloprovincialis sampled along the Moroccan coasts: Integrating biological and chemical data Biomarker Mytilus galloprovincialis
561 A. Geffard, J. C. Amiard and C. Amiard-Triquet 2002 Use of metallothionein in gills from oysters (Crassostrea gigas) as a biomarker: seasonal and intersite fluctuations Biomarker Crassostrea gigas
562 F. Regoli, S. Gorbi, D. Fattorini, S. Tedesco, A. Notti, N. Machella, R. Bocchetti, M. Benedetti and F. Piva 2006 Use of the land snail Helix aspersa as sentinel organism for monitoring ecotoxicologic effects of urban pollution: an integrated approach Biomarker Helix aspersa
563 M. J. Bebianno and M. A. Serafim 2003 Variation of metal and metallothionein concentrations in a natural population of Ruditapes decussatus Biomarker Ruditapes decussatus
564 M. A. Serafim and M. J. Bebianno 2001 Variation of metallothionein and metal concentrations in the digestive gland of the clam Ruditapes decussatus: sex and seasonal effects Heavy metal Ruditapes decussatus
565 W. Smaoui-Damak, A. Hamza-Chaffai, M. J. Bebianno and J. C. Amiard 2004 Variation of metallothioneins in gills of the clam Ruditapes decussatus from the Gulf of Gabes (Tunisia) Heavy metal Ruditapes decussatus
566 L. Peric, V. Nerlovic, P. Zurga, L. Zilic and A. Ramsak 2017 Variations of biomarkers response in mussels Mytilus galloprovincialis to low, moderate and high concentrations of organic chemicals and metals Biomarker Mytilus galloprovincialis
567 R. Freitas, R. Martins, S. Antunes, C. Velez, A. Moreira, P. Cardoso, A. Pires, A. M. Soares and E. Figueira 2014 Venerupis decussata under environmentally relevant lead concentrations: Bioconcentration, tolerance, and biochemical alterations Biomarker Venerupis decussata
568 H. I. Falfushynska, L. L. Gnatyshyna, A. Farkas, A. Vehovszky, J. Gyori and O. B. Stoliar 2010 Vulnerability of biomarkers in the indigenous mollusk Anodonta cygnea to spontaneous pollution in a transition country Biomarker Anodonta cygnea
569 A. Arini, G. Daffe, P. Gonzalez, A. Feurtet-Mazel and M. Baudrimont 2014 What are the outcomes of an industrial remediation on a metal-impacted hydrosystem? A 2-year field biomonitoring of the filter-feeding bivalve Corbicula fluminea Metal Corbicula fluminea
570 Y. Hardivillier, V. Leignel, F. Denis, G. Uguen, R. Cosson and M. Laulier 2004 Do organisms living around hydrothermal vent sites contain specific metallothioneins? The case of the genus Bathymodiolus (Bivalvia, Mytilidae) Biomarker Bathymodiolus (Mytilidae)
571 M. Egg, M. Hockner, A. Brandstatter, D. Schuler and R. Dallinger 2009 Structural and bioinformatic analysis of the Roman snail Cd-Metallothionein gene uncovers molecular adaptation towards plasticity in coping with multifarious environmental stress Heavy metal Helix pomatia